Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (28): 5277-5280.doi: 10.3969/j.issn.2095-4344.2012.28.030

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Hypoxia and the metabolism of osteoblast and osteoclast

Zhao Xing-chen1, Tian Jing2   

  1. 1Second Medical School of Southern Medical University, Guangzhou 510282, Guangdong Province, China;
    2Orthopedic Center, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China
  • Received:2011-10-19 Revised:2011-11-22 Online:2012-07-08 Published:2012-07-08
  • Contact: Tian Jing, Professor, Associate chief physician, Master’s supervisor, Orthopedic Center, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China tian_jing6723@yahoo.com.cn
  • About author:Zhao Xing-chen, Second Medical School of Southern Medical University, Guangzhou 510282, Guangdong Province, China yaomeng0118@qq.com

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Abstract:

BACKGROUND: More and more researches have demonstrated that hypoxia is closely associated to osteoporosis.
OBJECTIVE: To summarize the effects of hypoxia on bone metabolism of osteoblast and osteoclast and to make further explanation about the mechanism of hypoxia in osteoporosis.
METHODS: A computer-based online search of literatures published from 2007 to 2011 related to hypoxia associated with bone metabolism and osteoporosis was performed in PubMed database, Wanfang database and VIP database using the key words of “hypoxia, bone metabolism, osteoblasts, osteoclasts, chronic obstructive pulmonary disease, high altitude, osteoporosis” in English and in Chinese.
RESULTS AND CONCLUSION: Hypoxia can promote the generation and bone resorption of osteoclasts. The effects of hypoxia on the generation of osteoclasts depend on oxygen concentration and duration of hypoxia. Hypoxia inducible factors activated primarily by hypoxia which can active the downstream gene expression to regulate the generation of osteoblasts and their functions. The osteoporosis resulted from chronic obstructive pulmonary diseases is related to hypoxia, glucocorticoid, systemic inflammatory response and other factors. The osteoporosis resulted from high altitude is mainly related to hypoxia.

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