Abstract:

BACKGROUND: Patients with type 2 diabetes are in high risk with osteoporosis. But the pathogenesis is not clear.
OBJECTIVE: To investigate the characteristics of bone metabolism and the changes of bone mineral density in male patients with type 2 diabetes.
METHODS: Totally 97 male patients with type 2 diabetes and 76 male patients without diabetes were included in this study. All the subjects were included from the clinic and the ward of the Department of Geriatrics in Peking University Hospital from September 2008 to January 2010. The diagnostic standards accorded with diabetes formulated by WHO (1999). Patients with high serum creatinine level or with diabetic nephropathy were excluded. The level of serum osteoprotegerin (OPG), bone gla-protein (BGP), tartrate-resistant acid phosphatase (TRAP), bone alkaline phosphatase (BAP) and C-telopeptide of type-I collagen (CTX) were measured by ELISA. Clinical data and some biochemical items were collected simultaneously. The bone mineral density was determined by dual X-ray bone densitometer. 
RESULTS AND CONCLUSION: Compared with none diabetes group, the male patients with type 2 diabetes had no difference in bone mineral density of different regions (P > 0.05). But the OPG level and CTX level increased significantly in diabetes group   (P < 0.05). BGP, BAP and TRAP had no obvious changes (P > 0.05). It indicated that BGP and CTX play roles in the pathogenesis of diabetic osteoporosis.