Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (34): 6317-6320.doi: 10.3969/j.issn. 2095-4344.2012.34. 010

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Application of nano-collagen basal bone in repairing bone defects of periapical and periodontal diseases

Li Rui1, Wang Chun-lan2, Fan Yue-jing2, Lian Xiao-jie3   

  1. 1Department of Prosthodontics, Stomatology Hospital of Tianjin Medical University, Tianjin 300070, China;
    2Department of Stomotology, the Second Hospital of Tianjin Medical University, Tianjin 300211,China;
    3Department of Materials Science and Engineering, Tsinghua University, Beijing 100054, China
  • Received:2012-01-29 Revised:2012-03-19 Online:2012-08-19 Published:2012-08-19
  • About author:Li Rui☆, Doctor, Lecturer, Department of Prosthodontics, Stomatology Hospital of Tianjin Medical University, Tianjin 300070, China lirui198228@163.com

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Abstract:

BACKGROUND: Nano-collagen basal bone is a synthetic bionic bone and its structure is similar to natural cancellous bone structure, which can promote new bone formation with biodegradable absorption.
OBJECTIVE: To evaluate the repair effect of nano-collagen basal bone on periodontal and periapical bone defects.
METHODS: ①Totally 50 cases were selected and they were failure of root canal treatment and their periapical bones were destroyed more than 1 cm×1 cm. After scratch in root apex was scraped, 18 cases of them were implanted with nano collagen basal bone (experimental group), and 14 cases were implanted with Relive artificial bone (control group), while 18 cases were given nothing (blank control group). ②Twenty-three cases of bone defects from periodontal disease in vertical absorption were selected. A total of 17 cases underwent periodontal flap surgery and nano-collagen basal bone implantation, while 6 cases underwent periodontal flap surgery and Relive artificial bone implantation.
RESULTS AND CONCLUSION: ①Periapical bone defects: The bony union and calcification extent of the experimental group and control group had no significant difference at month 6 postoperatively, but were both higher than those of the blank control group (P < 0.01). ②Chronic periodontitis: The depth of pocket, adhesion loss and gums bleeding index were improved significantly in the experimental group and control group at month 6 postoperatively (P < 0.05), but there was no significant difference between the two groups (P > 0.05). Moreover, in the regions of angle-shaped and vertical absorption, bone height increase was found with new attachment formed. These findings suggest that nano-collagen basal bone can accelerate the reconstruction of normal structure in bone defects and promote the early regeneration of bone defects.

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