Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (36): 6827-6833.doi: 10.3969/j.issn.2095-4344.2012.36.032

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Surface markers of lung cancer stem cells

Yu Hong   

  1. Tumor Prevention and Cure Institute of Jilin Province, Changchun 130012, Jilin Province, China
  • Received:2012-05-15 Revised:2012-07-10 Online:2012-09-02 Published:2012-09-02
  • About author:Yu Hong, Associate researcher, Master’s supervisor, Tumor Prevention and Cure Institute of Jilin Province, Changchun 130012, Jilin Province, China yuhongnew@yahoo.com.cn

Abstract:

BACKGROUND: Detecting, tracking and monitoring the surface markers of cancer stem cells can provide important help for tumor diagnosis and biological treatments, such as immunotherapy.
OBJECTIVE: To review the articles on the surface markers of cancer stem cells in order to provide the reference theoretical basis for tumor diagnosis and improving the treatment methods and life quality.
METHODS: The SCI database was searched for the articles on the surface markers of cancer stem cells published from 2002 to 2011. The key words were “cancer stem cell, lung cancer” in English and Chinese. A total of 110 articles were screened out and finally 18 articles were included to review according to the inclusion criteria.
RESULTS AND CONCLUSION: Lung cancer is one of the malignant tumors with highest morbidity and mortality in the world. Detection of lung cancer stem cell surface marker, CD133, can help to study the occurrence, development and proliferation and maintaining process of tumors, and CD133 can provide relevant information for targeted biological treatments of lung cancer. With the deepening of the study, the cancer stem cell surface markers cannot only be applied for the early diagnosis of the tumor, but also be applied for the biological treatment of the tumor.

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