Improvement and evaluation of modeling method in animal models of osteoporosis

doi:10.3969/j.issn.2095-4344.2016.05.025

Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (5): 754-759.doi: 10.3969/j.issn.2095-4344.2016.05.025

Improvement and evaluation of modeling method in animal models of osteoporosis

Zhang Chun-li, Li Zhong-hai, Zhou Ying, Liu Yan, Hou Shu-xun

Department of Orthopedic Surgery, First Affiliated Hospital of General Hospital of PLA, Orthopedic Institute of PLA, Beijing Bone Implantable Medical Devices Engineering Technology Research Center, Beijing 100048, China

Received:2015-12-23 Online:2016-01-29 Published:2016-01-29
Contact: Hou Shu-xun, Chief physician, Department of Orthopedic Surgery, First Affiliated Hospital of General Hospital of PLA, Orthopedic Institute of PLA, Beijing Bone Implantable Medical Devices Engineering Technology Research Center, Beijing 100048, China Corresponding author: Li Zhong-hai, M.D., Attending physician, Department of Orthopedic Surgery, First Affiliated Hospital of General Hospital of PLA, Orthopedic Institute of PLA, Beijing Bone Implantable Medical Devices Engineering Technology Research Center, Beijing 100048, China
About author:Zhang Chun-li, Master, Technician-in-charge, Department of Orthopedic Surgery, First Affiliated Hospital of General Hospital of PLA, Orthopedic Institute of PLA, Beijing Bone Implantable Medical Devices Engineering Technology Research Center, Beijing 100048, China
Supported by:
the National Natural Science Foundation of China, No. 81201380; a Special Financial Grant from China Postdoctoral Science Foundation, No. 2015T81101; the Natural Science Foundation of Beijing City, No. 7153174

Abstract

Abstract:

BACKGROUND: Animal models of osteoporosis play an important role in the research of the pathogenesis, occurrence and development of osteoporosis, as well as in the clinical diagnosis, prevention and treatment of osteoporosis.
OBJECTIVE: To summarize and discuss the establishment and research ideas of osteoporosis models, explore the current situation and advance of osteoporosis models, compare the advantages and disadvantages of various methods, and provide evidence for clinical investigation.
METHODS: A computer-based online search was conducted in SinoMed, VIP, Wanfang and PubMed databases by using the key words of “animal model, osteoporosis” from January 1969 to October 2015. The language was limited to both Chinese and English. Relevant articles were screened according to inclusion and exclusion criteria. The documents about the methods of osteoporosis model preparation, method improvement as well as their advantage and disadvantage were summarized.
RESULTS AND CONCLUSION: A total of 576 articles were included. Among them, articles published earlier, duplicated, and similarly were excluded, and 53 articles were finally included. Various animal models of osteoporosis may only focus on the certain causes, certain stage, some of the main symptoms and some pathophysiological changes of disease. Accordingly, appropriate modeling methods and experimental animals should be selected based on research objective. Rat undergoing castration is the most commonly used model in the modeling of osteoporosis. Among drug methods for constructing osteoporosis model, glucocorticoids is the most commonly used one. Disuse method and nutritional method have limitations, and always combined with castration and drug methods. The effects of gene transfer, gene mutation and brain-derived model deserve further investigation.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Zhang Chun-li, Li Zhong-hai, Zhou Ying, Liu Yan, Hou Shu-xun. Improvement and evaluation of modeling method in animal models of osteoporosis[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(5): 754-759.

Figures/Tables 3

References

[1]      Fonseca H, Moreira-Gonçalves D, Coriolano HJ, et al. Bone quality: the determinants of bone strength and fragility. Sports Med. 2014;44(1):37-53.
[2]      Rachner TD, Khosla S, Hofbauer LC. Osteoporosis: now and the future.Lancet, 2011;377:1276-1287.
[3]      Rodgers JB, Monier-Faugere MC, Malluche H. Animal models for the study of bone loss after cessation of ovarian function. Bone. 1993;14(3):369-377.
[4]      Pavlos PL, Theodoros TX, Sofia ET. The laboratory rat as an animal model for osteoporosis research. Comp Med. 2008; 58(5):424-430.
[5]      Jilka RL. The relevance of mouse models for investigating age-related bone loss in humans. J Gerontol A Biol Sci Med Sci. 2013;68(10):1209-1217.
[6]      Costa LA, Lopes BF, Lanis AB, et al. Bone demineralization in the lumbar spine of dogs submitted to prednisone therapy. J Ver Pharmacol Ther. 2010;33(6):583-586.
[7]      Havill LM, Levine SM, Newman DE, et al. Osteopenia and osteoporosis in adult baboons (Papio hamadryas). J Med Primatol. 2008;37(3):146-153.
[8]      Scholz-Ahrens KE, Delling G, Stampa B, et al. Glucocorticosteroid- induced osteoporosis in adult primiparous Gottingen miniature pigs: effects on bone mineral and mineral metabolism. Am J Physiol Endocrinol Metab. 2007; 293(1):E385-E395.
[9]      Reinwald S, Burr D. Review of nonprimate, large animal models for osteoporosis research.J Bone Miner Res. 2008; 23(9):1353-1368.
[10]    虞惊涛,马信龙,马剑雄.骨质疏松动物模型评价方法[J].中华骨质疏松和骨矿盐疾病杂志,2014,(1):66-70.
[11]    Matsushita?M, ?Tsuboyama?T, Kasai?R,? et?al.? Age-related?changes?in?bone?mass?in?the?senescence-accelerated?mouse (SAM).?SAM-R/3 ?and?SAM-P/6? as?new?murine?models?for?senile?osteoporosis. ?Am? J Pathol. 1986;125(2):276-283.
[12]    Cheng M, Wang Q, Fan Y, et al. A traditional chinese herbal preparation, er-zhi-wan, prevent ovariectomy-induced osteoporosis in rats. J Ethnopharmacol. 2011;138(2):279-285.
[13]    Lucinda LMF, Vieira BJ, Oliveira TT, et al. Evidences of osteoporosis improvement in wistar rats treated with ginkgo biloba extract: a histomorphometric study of mandible and femur. Fitoterapia. 2010;81(8):982-987.
[14]    Egermann M, Goldhahn J, Schneider E. Animal models for fracture treatment in osteoporosis. Osteoporos Int. 2005; 16:S129-S138.
[15]    Yao W, Hadi T, Jiang YB, et al. Basic fibroblast growth factor improves trabecular bone connectivity and bone strength in the lumbar vertebral body of osteopenic rats. Osteoporos Int. 2005; 16(12):1939-1947.
[16]    Mandadi K, Ramirez M, Jayaprakasha GK, et al. Citrus bioactive compounds improve bone quality and plasma antioxidant activity in orchidectomized rats. Phytomedicine. 2009;16(6-7): 513-520.
[17]    Sigrist IM, Gerhardt C, Alini M, et al. The long-term effects of ovariectomy on bone metabolism in sheep. J Bone Miner Metab. 2007;25(1):28-35.
[18]    Chiang S, Liao J, Pan T. Effect of bioactive compounds in lactobacilli-fermented soy skim milk on femoral bone microstructure of aging mice. J Sci Food Agric. 2012;92(2): 328-335.
[19]    Shimizu M, Tsuboyama T. animal models for bone and joint disease. Genetic analysis of low bmd in samp6 mice. Clin Calcium. 2011;21(2):209-216.
[20]    Motyl KJ, Mccabe LR. Leptin treatment prevents type i diabetic marrow adiposity but not one loss in mice. J Cell Physiol. 2009; 218(2):376-384.
[21]    Stoker NG, Epker BN. Age changes in endosteal bone remodeling and balance in rabbit. J Dent Res. 1971;50(6):1570.
[22]    Castaneda S, Calvo E, Largo R, et al. Characterization of a new experimental model of osteoporosis in rabbits. J Bone Miner Metab. 2008;26(1):53-59.
[23]    Baofeng L, Zhi Y, Bei C, et al. Characterization of a rabbit osteoporosis model induced by ovariectomy and glucocorticoid. Acta Orthop. 2010;81(3):396-401.
[24]    Saville PD. Changes in skeletal mass and fragility with castration in the rat: a model of osteoporosis. J Am Geriatr Soc. 1969;17(2): 155-166.
[25]    Peng ZQ, Väänänen HK, Zhang HX, et al. Long-term effects of ovariectomy on the mechanical properties and chemical composition of rat bone. Bone. 1997;20(3):207-212.
[26]    郭峰,?李正南,?刘晋平,?等.?六月龄大鼠去卵巢后建立骨质疏松症模型的可行性[J].?中国组织工程研究,?2012,?16(24):4459-4462.
[27]    Egermann M, Goldhahn J, Schneider E. Animal models for fracture treatment in osteoporosis. Osteoporos Int. 2005;16: 129-138.
[28]    Weinstein RS, Jilka RL, Parfitt AM, et al. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest. 1998;102(2):274-282.
[29]    Parfitt AM, Villanueva AR, Foldes J, et al. Relations between histologic indices of bone formation: implications for the pathogenesis of spinal osteoporosis. J Bone Miner Res. 1995;10(3):466-473.
[30]    Rizzoli R, Biver E. Glucocorticoid-induced osteoporosis: who to treat with what agent? Nat Rev Rheumatol. 2015;11(2):98-109.
[31]    Xia X, Kar R, Gluhak-Heinrich J, et al. Glucocorticoid-induced autophagy in osteocytes. J Bone Miner Res. 2010;25(11): 2479-2488.
[32]    Oršoli? N, Golu?a E, Diki? D, et al. Role of flavonoids on oxidative stress and mineral contents in the retinoic acid-induced bone loss model of rat. Eur J Nutr. 2014;53(5):1217-1227.
[33]    Allen SP, Maden M, Price JS. A role for retinoic acid in regulating the regeneration of deer antlers. Dev Biol. 2002;251(2):409-423.
[34]    刘和娣,李星海,佟晓旭,等.地塞米松与维甲酸致大鼠骨质疏松动物模型的比较[J].中国病理生理杂志,2004,20(4):697-699.
[35]    Ponnapakkam T, Katikaneni R, Nichols T, et al. Prevention of chemotherapy-induced osteoporosis by cyclophosphamide with a long-acting form of parathyroid hormone. J Endocrinol Invest. 2011;34(11):392-397.
[36]    Jeremiah MP, Unwin BK, Greenawald MH, et al. Diagnosis and Management of Osteoporosis. Am Fam Physician. 2015;92(4): 261-268.
[37]    李杰,王义生,李月白,等.乙醇对骨髓基质细胞增殖及分化的影响[J].中国骨质疏松杂志,2004,10(1)52-53.
[38]    齐振熙,王明.乙醇性骨质疏松症的动物模型研究[J].中国骨伤, 2005,18(12):735-736.
[39]    Giangregorio L, Blimkie CJ. Skeletal adaptations to alterations in weight-bearing activity: a comparison of models of disuse osteoporosis. Sports Med. 2002;32(7):459-476.
[40]    Jee WS, Ma Y. Animal models of immobilization osteopenia. Morphologie. 1999;83(261):25-34.
[41]    Martín Jiménez JA, Consuegra Moya B, Martín Jiménez MT. Nutritional factors in preventing osteoporosis. Nutr Hosp. 2015; 32 Suppl 1:49-55.
[42]    Omi N, Ezawa I. Animal models for bone and joint disease. Low calcium diet-induced rat model of osteoporosi. Clin Calcium. 2011;21(2):173-180.
[43]    Kanzaki S, Ito M, Takada Y, et al. Resorption of auditory ossicles and hearing loss in mice lacking osteoprotegerin. Bone. 2006; 39(2):414-419.
[44]    Geoffroy V, Kneissel M, Fournier B, et al. High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage. Mol Cell Biol. 2002;22(17):6222-6233.
[45]    Sekiya H, Murakami T, Saito A, et al. Effects of the bisphosphonate risedronate on osteopenia in OASIS-deficient mice. J Bone Miner Metab. 2010;28(4):384-394.
[46]    Suzuki H, Amizuka N, Oda K, et al. Histological and elemental analyses of impaired bone mineralization in klotho-deficient mice. J Anat. 2008;212(3):275-285.
[47]    Enomoto T, Furuya Y, Tomimori Y, et al. Establishment of a new murine model of hypercalcemia with anorexia by overexpression of soluble receptor activator of NF-kappaB ligand using an adenovirus vector. J Bone Miner Metab. 2011;29(4):414-421.
[48]    Price C, Herman BC, Lufkin T, et al. Genetic variation in bone growth patterns defines adult mouse bone fragility. J Bone Miner Res. 2005;20(11):1983-1991.
[49]    Seeman E. Reduced bone formation and increased bone resorption: rational targets for the treatment of osteoporosis. Osteoporos Int. 2003;14 Suppl 3:S2-S8.
[50]    Ferguson VL, Ayers RA, Bateman TA, et al. Bone development and age-related bone loss in male C57BL/6J mice. Bone. 2003;33(3):387-398.
[51]    刘锡仪,刘浩宇.大鼠脑源性骨质疏松动物模型[J].中国骨质疏松杂志,2008,14(3):143-147.
[52]    Oheim R, Beil FT, Köhne T, et al. Sheep model for osteoporosis: sustainability and biomechanical relevance of low turnover osteoporosis induced by hypothalamic-pituitary disconnection. J Orthop Res. 2013;31(7):1067-1074.
[53]    Castiglioni S, Cazzaniga A, Albisetti W, et al. Magnesium and osteoporosis: current state of knowledge and future research directions. Nutrients. 2013;5(8):3022-3033.

Improvement and evaluation of modeling method in animal models of osteoporosis

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