Rabbit is suitable for establishing an animal model of rhino-sinusitis

doi:10.3969/j.issn.2095-4344.2014.18.008

Abstract

Abstract:

BACKGROUND: Using experimental animals to simulate diseases of human being is the basis of studying etiology and treatment of the diseases, so the diseases of nasal cavity and sinus need suitable experimental animals as models.
OBJECTIVE: To observe the regional anatomy of rhino-sinus in rabbits and its performance through CT imaging, and to discuss the feasibility of applying a rabbit model to the study of animal rhino-sinusitis.
METHODS: Routine coronal and axial scanning images of rhino-sinus of New Zealand rabbits were performed through Discovery CT750 HD. The rhino-sinus anatomy was then observed.
RESULTS AND CONCLUSION: The nasal septum is located on both sides of the nasal cavity. The lateral wall of rabbit nasal is composed of maxillary turbinate, middle turbinate, the inside of the middle turbinate and inferior turbinate. The maxillary sinus cavity is the largest one and ethmoid sinus, sphenoid sinus and frontal sinus are relatively much smaller. All these sinuses are paired and symmetrical. The rhino-sinus in rabbit is displayed clearly in CT scan. The anatomical location of rabbit is similar to that of human; however, the maxillary sinus of rabbit is greater than that of human correspondingly, which is suitable for operating and applying to surgical anatomy and imaging analysis. The rabbit model of rhino-sinus can be applied to simulate human rhino-sinusitis.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

全文链接：

Key words: sinusitis, paranasal sinuses, nasal cavity, models, animal

CLC Number:

R318

Xie Dao-yu, Ju Jian-bao, Yu Hai-ling, Li Na, Hao Da-peng, Sui Ai-hua. Rabbit is suitable for establishing an animal model of rhino-sinusitis[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(18): 2830-2835.

Figures/Tables 1

Quantitative analysis of experimental animals All rabbits were included in the final analysis. Anatomical observation of rhino-sinus structure of rabbits The rabbit nose consists of maxillary bone, ethmoid bone, and nasal bone. A large dark-red structure can be found at each lateral wall of the nasal cavity. This structure looks like a “coil” and is referred to as the inferior turbinate. A reddish uplift structure can be found at the post of the inferior turbinate. This structure looks like a three-layer ladder and is referred to as the middle turbinate. These structures are in substantially longitudinal direction. The maxillary sinus is divided into two or three parts with different sizes and then disconnected. The maxillary sinus-ostium is the inner wall of the maxillary sinus and is the contact channel between the nasal cavity and the maxillary sinus, which is the largest and most important sinus in rabbits. Ethmoid sinus, located in the posterior side post higher side of the maxillary sinus, consists of many small air cells similar to those in human. The mucosa of the ethmoid sinus is thinner than that of the maxillary sinus. The position of each ostium of the sinus of rabbit is similar to that of human (Figure 1). Imaging observation of rhino-sinus structure of rabbits The bilateral nasal cavity, sinus and nasal bone are shown clearly in the CT scans. The nasal septum is located on both sides of the nasal cavity as the human beings. The turbinate structure is visible at the lateral nasal, and a low-density mass shadow can be observed at both sides in front of lateral wall of the nasal cavity. The anatomical area of the maxillary sinus is shallow, and the sinus cavity with longitudinal elliptic shape is the largest. The ethmoid sinus is in the posterior high side of the maxillary sinus and consists of many air cells. Sphenoid and frontal sinuses are small (Figure 2)."

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