Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (51): 9567-9573.doi: 10.3969/j.issn.2095-4344.2012.51.013

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Biocompatibility of bone marrow mesenchymal stem cells with bladder extracellular matrix

Li Xin-hui, Liao Wen-biao, Li Yong-wei, Song Chao, Yang Si-xing   

  • Online:2012-12-16 Published:2012-12-16

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Abstract:

BACKGROUND: In the process of urinary tract defect recondition, the composite of bone marrow mesenchymal stem cells-bladder extracellular matrix is expected to form the epithelium, muscularis and vascularization.
OBJECTIVE: To observe the biocompatibility of bone marrow mesenchymal stem cells with bladder extracellular matrix.
METHODS: Passage 4 rabbit bone marrow mesenchymal stem cells were seeded into bladder extracellular matrix of allogeneic with a density of 1.0×106/mL. The separated cultured bone marrow mesenchymal stem cells were regarded as control. The growth curves of the two groups were drawn and the difference between them was evaluated.
RESULTS AND CONCLUSION: Bone marrow mesenchymal stem cells could attach, mitosis and growth on the surface of bladder extracellular matrix, and the cell growth curve was similar with that of the control group. This indicated that the bone marrow mesenchymal stem cells that grow well on the surface of bladder extracellular matrix.