Abstract:

BACKGROUND: Studies have shown that transforming growth factor beta 1 (TGF-β1) can promote wound healing and it is also an important growth factor to stimulate scar formation. TGF-β1 and TGF-β1/Smads signal transduction pathway have a significant relationship with scar formation.
OBJECTIVE: To further explore the molecular mechanisms of scar formation by studying TGF-β1/Smads signal transduction pathway in the scar formation process.
METHODS: By searching CNKI, VIP and PubMed in 1995-10/2010-10 using keywords of “scar, transforming growth factor β1, Smad”, we screened papers focusing on scar formation and TGF-β1/Smads signal transduction pathway that published recently in authoritative journals at home and abroad.
RESULTS AND CONCLUSION: Totally 27 relevant papers were included. These studies have shown that TGF-β1/Smads signal transduction pathway is involved in scar formation, and the occurrence of pathological scar can be lead through the various aspects of intervention in the way. TGF-β1 can play its basic biological functions via signal transduction. Therefore, the in-depth study of TGF-β1 signal transduction pathway and its controlling can further explore mechanisms of scar formation. Based on the above findings, it is beneficial for intervention of scar formation using biological engineering technology at the molecular level so that the cells can timely appear with proliferation, differentiation, and apoptosis, playing their functions. Finally, the wound healing becomes more ideal.