Abstract:

BACKGROUND: Cutting mechanical performance indexes are a reliable method for quantitative evaluation of osteoporosis after drug treatment.
OBJECTIVE: To establish animal models of osteoporosis and to compare the changes in cutting mechanical performance in rat models of osteoporosis after different drug interventions.
METHODS: Fifty rats were selected to prepare models of osteoporosis by removal of both ovaries, and then randomized into five groups: model group with no treatment, compound Chinese medicine group with 0.9 g/kg Chinese medicine per day, alendronate group with 1 mg/kg alendronate per day, vitamin K group with 0.1 mg/kg vitamin K per day, calcium supplement group with 2 mg/kg calcium supplement per day. Another 10 rats served as normal control group. Electronic universal testing machine was used for shear force determination.
RESULTS AND CONCLUSION: Maximum shear force and maximum shear stress in the model group were lower than those in the normal control, compound, alendronate and vitamin K groups (P < 0.05). No difference was found in the maximum shear force and maximum shear stress between the model and calcium supplement groups and between the compound and normal control groups. These results suggested that Chinese medicine, western medicine and vitamin K have a certain effect on osteoporosis rats, especially Chinese medicine. However, calcium supplement has no obvious effect on osteoporosis.