Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (43): 8133-8138.doi: 10.3969/j.issn.2095-4344.2012.43.031

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Progress and prospect of scaffold materials for tissue-engineered heart valves

Li Wen-tong, Yu Ben-tong   

  1. Department of Cardiothoracic Surgery, the First Affiliated Hospital of Nanchang University, Nanchang 33006, Jiangxi Province, China
  • Received:2012-01-07 Revised:2012-02-10 Online:2012-10-21 Published:2012-10-21
  • About author:Li Wen-tong, Master, Department of Cardiothoracic Surgery, the First Affiliated Hospital of Nanchang University, Nanchang 33006, Jiangxi Province, China tongge87821@ sina.com

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Abstract:

BACKGROUND: The mechanical and biological valves currently available for clinical use have crucial limitations. But tissue-engineered heart valves can avoid these problems and become an ideal substitute for biological valves.
OBJECTIVE: To review the progress in the research of scaffold materials for tissue-engineered heart valves.
METHODS: A computer-based online search of Wanfang and PubMed databases from 1990 to 2011 was conducted. The key words were “tissue engineering, heart valve, scaffold materials” in Chinese and English, respectively. A total of 147 articles were retrieved, and finally 61 articles were included in result analysis.
RESULTS AND CONCLUSION: At present, heart valve replacement is the primary surgical treatment for heart valve diseases. Neither mechanical nor biologic heart valve is an ideal substitute, which has significant limitations in terms of durability, growth potential, compatibility, resistance to infection. However, the tissue-engineered heart valve that is a living organ with the capability for growth, repair and remodeling in the same way that the native heart valve does has the potential to be an ideal valve substitute.

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