Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (43): 8105-8110.doi: 10.3969/j.issn.2095-4344.2012.43.026

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A new development of silk fibroin scaffolds in tissue engineering

Xie Min-kai, Xu Yue-min   

  1. Department of Urology, Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China
  • Received:2012-01-07 Revised:2012-02-16 Online:2012-10-21 Published:2012-10-21
  • Contact: Xu Yue-min, Chief physician, Doctoral supervisor, Department of Urology, Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China xuyuemin@263.net
  • About author:Xie Min-kai☆, Studying for doctorate, Department of Urology, Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China xieminkai@ hotmail.com

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Abstract:

BACKGROUND: Silk fibroin scaffolds have been recommended to use in tissue-engineered bone and cartilage, tendon, vessel, nerve, and bladder.
OBJECTIVE: To summarize the application and current development of silk fibroin scaffolds in the fields of biomaterials and tissue engineering.
METHODS: An online search was conducted by the first author in PubMed database and CNKI database to identify the articles related to silk fibroin scaffold preparation technique, modification of silk fibroin and silk fibroin tissue engineering published from January 2000 to November 2011.
RESULTS AND CONCLUSION: Silk fibroin scaffolds has excellent mechanical strength, slow biodegradability, superior biocompatibility and processability. And they can support various cells to attach, differentiate and grow. The scaffolds have been applied in tissue engineering studies, such as artificial ligament, blood vessels, bone, nerve tissue and so on. To date, diverse biologicals, such as growth factors or cytokines, were incorporated therein silk fibroin scaffolds, to further expand the application range in tissue engineering.

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