Abstract:

BACKGROUND: Bone morphogenetic proteins can enhance osteogenic differentiation and bone formation efficiently. Bone morphogenetic protein 9 is one of the most effective Bone morphogenetic proteins to induce osteogenic differentiation. However, it is one of the Bone morphogenetic proteins least studied.
OBJECTIVE: To review the research about bone morphogenetic protein 9 inducing osteogenic differentiation and its application in the treatment of many bony and musculoskeletal disorders at home and abroad in recent years.
METHODS: Bone morphogenetic protein 9 relevant articles from CNKI and PubMed databases from 2001-01 to 2011-06 were retrieved by computer. The articles published during the recent 5 years in the authorized journals related to this subject were collected. The key words were “bone morphogenetic protein 9, osteogenic differentiation, bone fracture, spinal fusions, tumor” in Chinese and English, respectively. There were 91 articles after the initial survey. A total of 34 articles related to BMP were included according to inclusion criteria for review.
RESULTS AND CONCLUSION: So far, several studies have shown that many growth factors can promote bone formation, and bone morphogenetic proteins are probably the most effective regulatory factor in the process of bone tissue formation. Bone morphogenetic protein 9, one of the bone morphogenetic protein family, not only can powerfully induce the osteoblast differentiation of mesenchymal stem cells and muscle cell preosteoblasts, but also play an important role in chondrogenesis, and its mechanism of inducing bone formation does not totally depend on the traditional classical BMP signal pathway. Animal experiments proved that bone morphogenetic proteins can also promote fracture healing, induce spinal fusions and regulate the behavior of tumor. Therefore, bone morphogenetic protein 9 has a bright future in the treatment of skeletal system diseases.