Abstract:

BACKGROUND: Reports about one-dimension tensile property of the left coronary artery in aging spontaneously hypertensive animal models are few in China.
OBJECTIVE: To observe creep properties of left coronary artery in aging spontaneously hypertensive rats and Sprague Dawley rats.
METHODS: Twelve normal male Sprague Dawley rats (4 months old) and 12 aging spontaneously hypertensive male rats (12 months old) were selected and divided into normal Sprague Dawley group and spontaneously hypertensive group. Twelve samples from each group were selected and installed in electronic testing machine for the creep test, and they were given stress by 0.05%/s strain increases velocity at the simulating human body temperature of (36.5±0.1) ℃. The setting time was 7 200 seconds. Creep equations of these samples in the two groups were calculated by normalized analysis method.
RESULTS AND CONCLUSION: Creep curves of the two groups were changed in exponential relationship. In the initial 600 seconds, the strain changed rapidly, and it rose slowly as time prolonged. The strain increment in 7 200 seconds of normal Sprague Dawley group was more than that of spontaneously hypertensive group. There was a significant difference between the two groups (P < 0.05). It suggests that there are differences in creep properties of the left coronary artery between normal Sprague Dawley rats and aging spontaneously hypertensive rats.