Abstract:

BACKGROUND: Studies have found that some Chinese herbal medicines in the process of fracture healing can accelerate bone tissue remodeling by different ways to promote fracture healing.
OBJECTIVE: To study the influence of Dipsacaceae decoction on the expression of platelet derived growth factor-BB during orthodontic tooth movement.
METHODS: Twenty-seven rabbits were randomly divided into experimental group (n=12), control group (n=12), and blank control group (n=3). Mandibular first molars were moved bilaterally in the experimental and control groups. Then, 3 g/kg Dipsacaceae decoction was given orally to the experimental group, and the equal amount of saline was given orally to the control group. There was no treatment in the blank control group. After 1, 7, 14, 21 days, the distance of tooth movement was measured separately and then immunohistochemical analysis was performed for platelet derived growth factor-BB.
RESULTS AND CONCLUSION: After 7-, 14-, and 21-day loading, the tooth movement distance was greater in the experimental group than in the control group (P < 0.05). After orthodontic force was performed, the expression of platelet derived growth factor-BB was gradually increased with time in the experimental and control groups. After 7, 14 and 21 days, the experimental group had a higher expression of platelet derived growth factor-BB compared with the control group (P < 0.05). These point out that Dipsacaceae decoction can promote the orthodontic tooth movement in rabbits and increase the expression of platelet derived growth factor-BB.