Abstract:

BACKGROUND: Scaffold materials are the core of bone tissue engineering, and bone matrix as a carrier material is one kind of the scaffold materials that provides more effective therapeusis for bone defects.
OBJECTIVE: To especially introduce the application of freeze-dried demineralized bone matrix，deprotein bone matrix and acellular bone matrix in bone tissue engineering.
METHODS: The first author retrieved literatures from PubMed, CNKI, Wanfang databases with the key words of “bone tissue engineering, scaffold materials, demineralized bone matrix, deprotein bone matrix, acellular bone matrix, bone defect” in English and Chinese, respectively. The authority literatures summarized in bone tissue engineering field and published from 1994 to 2010 were included.
RESULTS AND CONCLUSION: The results indicate that freeze-dried demineralized bone matrix, deprotein bone matrix and acellular bone matrix display good biocompatibility, low antigenicity, and have no cytotoxicity. As carrier materials for bone tissue engineering, they have natural attributes of bones, such as porosities and bone conduction, which develops a new approach in bone defects repair.