Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (32): 6063-6070.doi: 10.3969/j.issn.2095-4344.2012.32.033

Previous Articles     Next Articles

Stem cell transplantation for treatment of liver cirrhosis

Wang Juan1, Shao Li-chun1, Guo Qing1, Kong Xin1, Chen Zhe2, Zhou Bo2, Yang Xiao-feng3   

  1. 1Department of Gastroenterology, the 463 Hospital of Chinese PLA, Shenyang 110042, Liaoning Province, China;
    2Shenzhen Beike Cell Engineering Research Institute, Shenzhen 518057, Guangdong Province, China；
    3Department of Hematology, the 463 Hospital of Chinese PLA, Shenyang 110042, Liaoning Province, China
  • Received:2012-02-03 Revised:2012-07-19 Online:2012-08-05 Published:2012-08-05
  • Contact: Yang Xiao-feng, Chief physician, Master’s supervisor, Department of Hematology, the 463 Hospital of Chinese PLA, Shenyang 110042, Liaoning Province, China Yxf463@yahoo.com.cn
  • About author:Wang Juan, Chief physician, Department of Gastroenterology, the 463 Hospital of Chinese PLA, Shenyang 110042, Liaoning Province, China w_chch@hotmail.com

PDF

505

Abstract:

BACKGROUND: Stem cell has self-renewal and differentiation capacity, and can differentiate into hepatic lineage cells. Studies have shown that stem cell transplantation have achieved good effect for the treatment of liver cirrhosis.
OBJECTIVE: To provide a new treatment for patients with liver cirrhosis according to umbilical cord blood stem cell transplantation, bone marrow stem cell transplantation, peripheral bloodstem cell transplantation for treatment of liver cirrhosis.
METHODS: A retrieval was performed for the literature of the stem cell transplantation for the treatment of liver cirrhosis, using key words liver/hepatic cirrhosis; decompensated cirrhosis, peripheral vein; stem cell; transplantation; umbilical cord blood stem cell; bone marrow stem cell; autologous bone marrow stem cell and peripheral blood stem cell between 2002-01 and 2011-12 in China National Knowledge Infrastructure (CNKI) database.
RESULTS AND CONCLUSION: Stem cells with self-renewing amplification and multi-differentiation potential can differentiate into a variety of functional cells under certain conditions. There were three kinds of stem cells in the treatment liver cirrhosis clinically at present, including umbilical cord blood stem cells, bone marrow stem cells, and peripheral blood stem cells. Although the clinical application of stem cell transplantation in the treatment of liver cirrhosis has just started, it has acquired good efficacy. The majority of patients receiving treatment showed improvement in clinical symptoms and liver function. The method is of simple, inexpensive, and can avoid immune rejection as well as without involving the ethical and other issues.

CLC Number: