Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (32): 6047-6052.doi: 10.3969/j.issn.2095-4344.2012.32.030

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MicroRNA affects bone marrow-derived stem cells, osteoblasts and osteoclasts in bone metabolism

Fan Long-kun1, Chen Yong2, Hua Ze-quan3   

  1. 1The General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China;
    2Department of Oral & Maxillofacial Surgery, Changzhou Municipal Central Hospital, Changzhou 061001, Hebei Province, China;
    3Department of Oral & Maxillofacial Surgery, the General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China
  • Received:2011-11-08 Revised:2012-02-01 Online:2012-08-05 Published:2012-08-05
  • Contact: Hua Ze-quan, Master, Master’s supervisor, Professor, Department of Oral & Maxillofacial Surgery, the General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China huazequan@sohu.com
  • About author:Fan Long-kun★, Master, Physician, the General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China flkun@sina.cn

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Abstract:

BACKGROUND: Recent studies have demonstrated that microRNA plays an important regulatory role in the differentiation of bone marrow mesenchymal stem cells (BMSCs).
OBJECTIVE: To summarize the role of microRNA in the differentiation of BMSCs and fully investigate the mechanism underlying differentiation of BMSCs, which would provide significance for preventing and treating osteoporosis.
METHODS: A computer online retrieval was performed by the first author in PubMed and Wanfang database to search papers regarding microRNA influencing bone metabolism by regulating BMSCs published between 1990 and 2008 with the key words microRNA,mesenchymal stem cells, bone metabolism” in Chinese or English. According to inclusion criteria, 30 papers were included for further analysis.
RESULTS AND CONCLUSION: MicroRNA influences self-renewal and differentiation of BMSCs by regulating many transcription factors, growth factors and signal pathway. Specific microRNA related to BMSC differentiation was screened out using high-throughput technique. The underlying molecular mechanism would provide important significance for clarifying the mechanism underlying bone metabolism disorders induced by abnormal BMSC differentiation, such as osteoporosis. Studying the mechanism underlying microRNA effects on BMSC differentiation would provide a new thought for preventing and treating metabolic bone diseases.

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