Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (28): 5315-5320.doi: 10.3969/j.issn.2095-4344.2012.28.037

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Relationship between surfactant protein A polymorphism and chronic obstructive pulmonary disease in Xinjiang Mongolian population

Guan Jian1, 2, Xu Yong-jian1, Xu Xi-lin2, Luo Shu-xin2, Ji Hong-zhi2   

  1. 1Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China;
    2Department of Respiratory Medicine, the First Affiliated Hospital of Medical College, Shihezi University, Shihezi 832008, Xinjiang Uygur Autonomous Region, China
  • Received:2012-03-02 Revised:2012-05-11 Online:2012-07-08 Published:2012-07-08
  • About author:Guang Jian☆, Studying for doctorate, Associate professor, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China; Department of Respiratory Medicine, the First Affiliated Hospital of Medical College, Shihezi University, Shihezi 832008, Xinjiang Uygur Autonomous Region, China guanjian6@163.com

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Abstract:

BACKGROUND: At present, the genetic pathogenesis of chronic obstructive pulmonary disease has not been fully understood yet. Surfactant protein A may play an important role in the pathogenesis of genetic susceptibility in chronic obstructive pulmonary disease, and there may be a racial difference.
OBJECTIVE: To investigate the relationship between surfactant protein A polymorphism and chronic obstructive pulmonary disease in Xinjiang Mongolian population.
METHODS: The case-control study was used in this study. DNAs were extracted from the peripheral blood of 119 smokers with chronic obstructive pulmonary disease and 116 healthy smokers from Mongolian population. Polymorphisms of rs1136451 and rs4253527 were determined by the Taqman PCR method.
RESULTS AND CONCLUSION: Genotypes frequencies were different between the chronic obstructive pulmonary disease and normal smokers for aa62 (χ2=7.164, P=0.028). There were also significant differences in allele genotype frequencies to the chronic obstructive pulmonary disease smokers (χ2=2.239, P=0.019). There were differences in genotype frequency stage II and stage Ⅲ of chronic obstructive pulmonary disease (χ2=8.721, P=0.013). Genotypes frequencies were not different between the chronic obstructive pulmonary disease and normal smokers for aa219 (χ2=0.367, P=0.545); there were also no differences in allele genotype (χ2=0.332, P=0.565). The polymorphism of aa62 (CCA/CCG, rs1136451) in surfactant protein A may be associated with the susceptibility to chronic obstructive pulmonary disease in Xinjiang Mongolian population.

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