Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (18): 3241-3244.doi: 10.3969/j.issn.1673-8225.2012.18.003

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Tolterodine effectively attenuates catheter related bladder discomfort in kidney transplantation patients*☆

Li Jin-feng, Feng Gui-wen, Wang Yue, Pang Xin-lu, Shang Wen-jun, Liu Lei   

  1. Department of Renal Transplantation, the First Affiliated Hospital of Zhengzhou University, Zhengzhou  450052, Henan Province, China
  • Received:2011-12-09 Revised:2011-12-29 Online:2012-04-29 Published:2012-04-29
  • Contact: Feng Gui-wen, Doctor, Associate chief physician, Department of Renal Transplantation, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China fengguiwen123@ 126.com
  • About author:Li Jin-feng☆, Doctor, Attending physician, Department of Renal Transplantation, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China jinfenglis512@126. com
  • Supported by:

     the Youth Foundation of the First Affiliated Hospital of Zhenzhou University, No. 2011-QN010*

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Abstract:

BACKGROUND: Renal transplantation requires long term use of indwelling catheter, which could easily cause bladder irritation.
OBJECTIVE: To assess the catheter related bladder discomfort using Overactive Bladder Symptom Score in kidney transplantation patients; to evaluate the efficiency of tolterodine in preventing catheter related bladder discomfort in kidney transplantation patients.
METHODS: A total of 102 living-related kidney transplant recipients were involved in this study. Indwelling catheters were used after transplant; and patients were treated with 4 mg/d tolterodine or the same dose of placebo, respectively. The recipient bladder discomfort was assessed using Overactive Bladder Symptom Score at different time points.
RESULTS AND CONCLUSION: The incidence and severity of urgency and urgency incontinence increased in kidney transplant patients with increasing catheter indwelling time. With the application of tolterodine, the incidence and severity of urgency and urgency incontinence decreased significantly. These findings indicate that regulated application of tolterodine may effectively prevent catheter related bladder discomfort in kidney transplantation patients.

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