Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (8): 1417-1420.doi: 10.3969/j.issn.1673-8225.2011.08.021

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Release characteristics of nano-silver gel versus nano-silver hydrogel in simulated body fluid

Zhou Liang1,2,3, Tang Jing-long2, Wang Chun-ren2, Chen Yan-mei4, Dong Zhe2, Li Zhong-liang1, Shao An-liang1, Zhou Guo-feng1, Xi Ting-fei1,5   

  1. 1School of Information & Engineering, Wenzhou Medical College, Wenzhou  325035, Zhejiang Province, China
    2National Institute for the Control of Pharmaceutical and Biological Products, Beijing  100050, China
    3Haimen Municipal People’s Hospital, Haimen  226100, Jiangsu Province, China
    4College of Engineering, Peking University, Beijing  100087, China
    5Shenzhen Research Institute, Peking University, Shenzhen  518057, Guangdong Province, China
  • Received:2010-11-22 Revised:2011-01-05 Online:2011-02-19 Published:2011-02-19
  • Contact: Xi Ting-fei, Doctoral supervisor, Researcher, School of Information & Engineering, Wenzhou Medical College, Wenzhou 325035, Zhejiang Province, China; Shenzhen Research Institute, Peking University, Shenzhen 518057, Guangdong Province, China xitingfei@tom.com
  • About author:Zhou Liang★, Studying for master’s degree, School of Information & Engineering, Wenzhou Medical College, Wenzhou 325035, Zhejiang Province, China; National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China; Haimen Municipal People’s Hospital, Haimen 226100, Jiangsu Province, China cannychow@foxmail.com

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Abstract:

BACKGROUND: Researches at home and abroad demonstrate that silver nanoparticles can migrate and accumulate in vivo, eventually leading to cytotoxicity and genotoxicity which increases with the accumulation level.   
OBJECTIVE: To observe the release characteristics of nano-silver gel and nano-silver hydrogel in simulated body fluid.
METHODS: Three kinds of nano-silver gel and three kinds of nano-silver hydrogel from six manufacturers were soaked in simulated body fluid, the release liquid was extracted at different time points, and then harvested for silver content analysis by using the extra high pressure microwave and the atom absorption spectrum instrument, at last, the release characteristics of these were analyzed and summarized.
RESULTS AND CONCLUSION: In the simulated body fluid, the release rate of three kinds of nano-silver gel was 3.59, 4.30 and 1.17 g/min respectively, the time to reach dynamic equilibrium was 40, 35, 70 minutes respectively; by comparison, the release rate of three kinds of nano-silver hydrogel was 5.14, 5.31 and 4.86 g/s respectively, the time to reach dynamic equilibrium was all 100 seconds. Due to the difference of carrier matrix, the release rate of nano-silver hydrogel was significantly higher than the nano-silver gel; different manufacturers and different techniques of silver nanoparticles, may lead to altered release rates of nano-silver gel, while the release rate of nano-silver hydrogel was not different.

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