Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (8): 1413-1416.doi: 10.3969/j.issn.1673-8225.2011.08.020

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Preparation and properties of chitosan/polyvinyl alcohol loaded with nano-silver for wound dressing

Zeng Xiao-feng1, Wei Kun1, Han Xue1, Luo Yun1, Shu Li-jun1, Wu Yuan1, Shen Zheng-yu2   

  1. 1College of Materials Science and Engineering, South China University of Technology; National Engineering Research Center for Human Tissue Function Reconstruction, Guangzhou   510640, Guangdong Province, China; 2Schllo of Biological Science and Engineering, South China University of Techology, Guangzhou  510640, Guangdong Praince, Chine
  • Received:2010-09-14 Revised:2010-10-15 Online:2011-02-19 Published:2011-02-19
  • Contact: Wei Kun, Doctor, Professor, College of Materials Science and Engineering, South China University of Technology; National Engineering Research Center for Human Tissue Function Reconstruction, Guangzhou 510640, Guangdong Province, China
  • About author:Zeng Xiao-feng★, Studying for master’s degree, College of Materials Science and Engineering, South China University of Technology; National Engineering Research Center for Human Tissue Function Reconstruction, Guangzhou 510640, Guangdong Province, China zengxiaofeng08@yahoo.com.cn
  • Supported by:

    the National High- Technology Research and Development Program of China (863 Program), No. 2007AA021908*, 2007AA021906*; the National Natural Science Foundation of China, No. 50732003U0834003*

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Abstract:

BACKGROUND: Antiseptic dressing is one of the important measures to prevent occurrence of invasive wound infection, but the long-term use of antibiotics can cause bacteria resistance. Meanwhile, antibacterial materials are combined with cotton fabric to obtain antiseptic dressing, poor biocompatibility, and should not be used for long-term coverage of wound.
OBJECTIVE: To prepare a good biocompatible, antibacterial anti-inflammatory of new antibacterial biological dressing, and to initially detect its biological properties.
METHODS: In the study, Ag/SiO2 nanocomposite was synthesized in an absorption phase nanoreactor formed in the ethanol/ water/NaOH solution; SiO2 powder loaded with silver was added into chitosan/polyvinyl alcohol reaction solution, chitosan/polyvinyl alcohol sponge containing Ag/SiO2 nanoparticles was prepared by acetalization reaction. The mechanical properties, surface topography, cytotoxicity and antibacterial properties of materials were detected.
RESULTS AND CONCLUSION: The material displayed porous structure, and had favorable moisture-adsorption rate, air permeability rate, moisture-retention rate, and high tensile strength; porosity of material was high, interspace of sponge was dense and uniform, the pore diameter was about 0.1-1 mm. The cytotoxicity test using MTT method suggested that the material had no significant cytotoxicity to fibroblasts of mouse and could promote the growth of fibroblasts. Materials on the staphylococcus aureus, escherichia coli, candida albicans, pseudomonas aeruginosa, salmonella typhi had a good bactericidal effect. These results indicated that the material not only possesses good mechanical properties, bioactivity and antibacterial activity, but also its synthesis procedure is simple. Therefore, the developed material can be applied for wound dressing.

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