Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (7): 1281-1284.doi: 10.3969/j.issn.1673-8225.2011.07.032

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Gene therapy in the repair and regeneration of peripheral nerve injury 

Li Jing-huan1, Tian Jing2   

  1. 1Second Medical School of Southern Medical University, Guangzhou  510282, Guangdong Province, China
    2Orthopaedia Center, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou  510282, Guangdong Province, China
  • Received:2010-11-10 Revised:2010-12-07 Online:2011-02-12 Published:2011-02-12
  • Contact: Tian Jing, Professor, Associate chief physician, Master’s supervisor, Orthopaedia Center, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China tian_jing6723@ yahoo.com.cn
  • About author:Li Jing-Huan, Second Medical School of Southern Medical University, Guangzhou 510282, Guangdong Province, China

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Abstract:

BACKGROUND: Functional recovery of peripheral nerve after repair is not ideal. Gene therapy provides a new method for repair peripheral nerve injury.
OBJECTIVE: The paper reviewed from three areas, including functional gene, transfer vector selection, and biological effects of gene translation factors, aimed to provide reference for gene therapy for peripheral nerve injury.
METHODS: A computer-based online search of PubMed and CNKI between 2006 and 2010 was performed to search related articles with the key words of “peripheral nerve injury, gene therapy, virus vector” both in English and Chinese. Literatures related to gene therapy for peripheral nerve injury were selected, in the same field, the articles published lately or published by authoritative journals were preferred.
RESULTS AND CONCLUSION: A total of 35 articles were searched by computer and 21 documents were included after screening. Currently, technology of gene therapy for peripheral nerve injury has matured, such as transgenic adenovirus bone morphogenetic protein 7 and Ad-32Ep65-Flag gene, the clinical repair of peripheral nerve is expected to become an important means.

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