Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (7): 1259-1263.doi: 10.3969/j.issn.1673-8225.2011.07.027

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Research and progress of tissue-engineered annulus fibrosus disci intervertebralis

Yan Zhong-sheng1, Xu Bao-shan1,2, Yang Qiang2, Xia Qun2 , He Jian1   

  1. 1Tianjin Medical University, Tianjin  300211, China
    2Second Ward of Spine, Tianjin Hospital, Tianjin  300211, China
  • Received:2010-11-23 Revised:2010-12-27 Online:2011-02-12 Published:2011-02-12
  • Contact: Xu Bao-shan, Doctor, Chief physician, Master’s supervisor, Second Ward of Spine, Tianjin Hospital, Tianjin 300211, China xubshn@yahoo.com.cn Yang Qiang, Doctor, Attending physician, Second Ward of Spine, Tianjin Hospital, Tianjin 300211, China yangqiang1980@ 126.com
  • About author:Yan Zhong-sheng★, Studying for master’s degree, Tianjin Medical University, Tianjin 300211, China sdyanzhongsheng@163.com
  • Supported by:

    Technology Advanced Program for the Returned Overseas Chinese Scholars of Department of the National Human Resources and Social Security*; the Science and Technology Project of Tianjin Health Bureau, No. 07KG1*; the Key Project of Technology Foundation for Tianijn Health Bureau, No. 2010KR08*

Abstract:

BACKGROUND: Tissue engineering is a new strategy that can permanently repair degenerated intervertebral disc. However, nucleus pulposus tissue engineering method cannot completely reconstruct the structure and function of intervertebral discs. Therefore, the corresponding anulus fibrosus tissue engineering is regarded as one of the major limiting factors for the treatment strategies of tissue-engineered intervertebral disc.
OBJECTIVE: To sum up the research and progress of tissue-engineered annulus fibrosus disci intervertebralis, and to provide theoretical foundation of tissue-engineered intervertebral disc.
METHODS: Pubmed database, CNKI database, and VIP database from 2000 to 2010 was retrieved by the first author with the key words of “tissue engineering, intervertebral disc, annulus fibrosus, seed cell, scaffold, growth factor” in Chinese and in English, respectively. Literatures were limited to Chinese and English languages. Seed cell source, the selection of scaffold materials, and growth factor of annulus fibrosus disci intervertebralis tissue engineering were summarized.
RESULTS AND CONCLUSION: A total of 106 literatures were obtained from computer screen, 34 of them were involved for summarization according to inclusion and exclusion criteria. At present the studies were concentrated on the construction of annulus fibrosus and nucleus pulposus tissues. And the construction of functional annulus fibrosus is still at the initial stage. The selection of the seed cells, scaffold materials and growth factors are still to be further studied. 

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