Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (7): 1174-1178.doi: 10.3969/j.issn.1673-8225.2011.07.008

Previous Articles     Next Articles

Age-related effect on Wnt-1 and osteoprotegerin expression in pressure side of periodontal tissue

Xu Lian-jing1, Qin Ming-qun2, Mao Jun-wu2, Huang Sheng-fu3   

  1. 1Guilin Medical College, Guilin  541004, Guangxi Zhuang Autonomous Region, China
    2Department of Stomatology, Affiliated Hospital of Guilin Medical College, Guilin  541001, Guangxi Zhuang Autonomous Region, China
    3Department of Orthodontics, Stomatological Hospital of Wuhan University, Wuhan  430079, Hubei Province, China
  • Received:2010-09-19 Revised:2011-01-06 Online:2011-02-12 Published:2011-02-12
  • Contact: Qin Ming-qun, Master, Professor, Master’s supervisor, Department of Stomatology, Affiliated Hospital of Guilin Medical College, Guilin 541001, Guangxi Zhuang Autonomous Region, China qmq@vip.sina.com
  • About author:Xu Lian-jing★, Studying for master’s degree, Guilin Medical College, Guilin 541004, Guangxi Zhuang Autonomous Region, China xulianjing825@163. com
  • Supported by:

    the Key Scientific Research Fund of Guangxi Health Bureau, No. 200980*

PDF

462

Abstract:

BACKGROUND: Osteoprotegerin (OPG) plays an important role in bone remodeling during orthodontic tooth movement. Wnt-1 is closely related with bone formation, but Wnt-1 correlated with orthodontic bone remodeling has not been reported.
OBJECTIVE: To compare age-related effect on periodontal tissue Wnt-1 during orthodontic tooth movement in rats and osteoprotegerin expression.
METHODS: A total of 40 male Wistar rats (6-week-old) and 40 male Wistar rats (24-week-old) were included. Orthodontic tooth movement model of rat molar mesial movement was prepared, the model was drawn at 1, 3, 7, and 14 days tooth movement. The expression of Wnt-1 and OPG in pressure side of periodontal tissue was detected by RT-PCR and immunohistochemistry method.
RESULTS AND CONCLUSION: OPG was expressed at the pressure side of periodontal tissues, which was stronger on days 3 and 7 than days 1 and 14; at the same time point, the OPG expression of pressure side of rats (6-week-old) was stronger than that of 24-week-old rats. Wnt-1 was not expressed at the pressure side of periodontal tissue in rats (6-week-old, 24-week-old). Wnt-1 protein expression of 6-week-old rats was existed at 3 days after tooth movement. Age factor is an important factor in orthodontic bone remodeling; however, Wnt-1 seems no correlation with orthodontic bone remodeling.

CLC Number: