Abstract:

BACKGROUND: Extracorporeal cardiac shock wave therapy (CSWT) can up-regulate angiogenic factors and its receptors, promote angiogenesis and collateral circulation establishment by introducing shock waves to myocardium, however, the specific mechanisms remain unclearly.
OBJECTIVE: To observe the influence of CSWT on the content of serum endothelial nitric oxide synthase (eNOS) in pigs following acute myocardial infarction (AMI).
METHODS: Pig AMI model was established by embolizing the distal of left anterior coronary artery. Following model preparation, pigs were randomly divided into 2 groups. In the experimental group received three CSWT at days 1, 3 and 5, 200 hits per point, totally 12 points, with 0.09 mJ/mm2 energy. Pigs with simple AMI were served as the control group. The serum eNOS level was detected by ELISA method before, immediate postoperative, and at days, 1, 3, 5, and weeks 1, 2, 3, and 4 after operation. 
RESULTS AND CONCLUSION: The eNOS level of both groups were obvious decreased at immediate postoperative than that before operation. At day 1 after CSWT, eNOS level was increased in the experimental group, which was still decreased in the control group. It revealed that CSWT play a positive effect on ischemia myocardium. The eNOS level reached a peak in the experimental group after 3 times of CSWT, lasted for 2-3 weeks, and began to decrease at week 4. The difference between the experimental group and control group had significance (P < 0.01). The results demonstrated that CSWT can treat AMI effectively by promoting eNOS expression.