Abstract:

BACKGROUND: Within a magnetic field, magnetic drug-loaded nanoparticles can implement targeted therapy, reduce systemic side effect. Also serving as a release carrier, magnetic drug microspheres can decrease administration frequency and achieve effective treatment.
OBJECTIVE: To prepare 5-Fluorouracil magnetic nanoparticles, and to estimate nanoparticles’ performance.
METHODS: Nanometer-sized magnetic release particles were prepared by an emulsifying-complex coacervation method with alginate-chitosan as the coating material, 5-Fluorouracil as model drug, Span80 as emulsifier, liquid paraffin as disperse medium. The shape, stability, magnetic responsiveness, structures, swelling action, release action in vitro of nanoparticles were investigated.
RESULTS AND CONCLUSION: The 5-Fluorouracil nanoparticles were spherical shape with a regular surface, fine dispersibility at a diameters of 100-300 nm. They have good stability and good magnetic responsiveness. To investigate the influence of Fe₃O₄ dosage, with the increase of Fe₃O₄ dosage, the magnetic responsiveness increased, while the loading capacity increased. The infrared results showed that the nanoparticles encapsulated with Fe₃O₄, and 5-Fluorouracil interacted with coating materials. The 5-Fluorouracil nanoparticles were immersed in three mediators of distilled water, 0.9% NaCl and phosphate buffer saline (pH=7.4), the hydrating rate and swelling ratios in distilled water were the highest, while the lowest in phosphate buffer saline (pH=7.4). The sustained-releasing ability of nanoparticles was well, and the releasing content counted for 53.20% of total drug within 50 hours.