Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (47): 8791-8794.doi: 10.3969/j.issn.1673-8225.2010.47.013

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Biodegradability and biocompatibility of ε-caprolactone and L-lactide copolym

Gao Xi-xiang1, Zhang Jian1, Chen Bing1, Yu Heng-xi1, Li Jian-xin1, Zhang Shu-wen1, Meng Yan1, Han Jian2, Ye Lin2, Feng Zeng-guo2   

  1. 1 Institute of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing   100053, China; 2 School of Materials Science & Engineering, Beijing Institute of Technology, Beijing   100081, China
  • Online:2010-11-19 Published:2010-11-19
  • Contact: Zhang Jian, Chief physician, Professor, Institute of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China vascsurgeon@yahoo.cn
  • About author:Gao Xi-xiang☆, Studying for doctorate, Institute of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China gxx810929@yahoo.com.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 30972944*

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Abstract:

BACKGROUND: Copolymers of ε-caprolactone and L-lactide have good mechanical property, and regulable degradation rate. They become popular as a tissue engineered vascular graft.
OBJECTIVE: To study the biodegradability and biocompatibility of ε-caprolactone and L-lactide copolymers.
METHODS: A kind of ε-caprolactone/L-lactide copolymer with different compositions and molecular weights was prepared by varying the monomer molar ratios in feed. The biodegradability was studied in lipase solution (accelerated degradation). The biocompatibility was also studied by implantation in vivo.
RESULTS AND CONCLUSION: The ε-caprolactone/L-lactide copolymer at 75/25 molar ratio has a great mechanical property through the biodegradation, as well as high biocompatibility in vivo. It is suitable for the preparation of artificial blood vessel of tissue engineering.

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