Biological properties of gradient bioactive coatings on titanium surface in the skull repair

doi:10.3969/j.issn.2095-4344.2016.12.015

Abstract

Abstract:

BACKGROUND: Titanium mesh has good clinical effect in repairing skull defects, but due to the lack of bone induction ability, the titanium mesh has a poor integration with the bone tissue.
OBJECTIVE: To observe the biological properties of the gradient bioactive coating materials on the titanium surface in the skull repair.
METHODS: Osteoblasts were co-cultured with the titanium mesh with or without gradient bioactive coatings for 14 days, and then cell proliferation was detected using MTT method. Seventy-one patients with skull defects were enrolled, including 43 males and 28 females, aged 15-60 years, and were subjected to skull repair using the titanium mesh with (observation group, n=3) or without (control group, n=38) gradient bioactive coatings. During the postoperative follow-up of 12 months, the repairing effects and adverse reactions were observed in the two groups.
RESULTS AND CONCLUSION: (1) In vitro cell culture: the cell proliferative ability was increased significantly in the observation group as compared with the control group at 8, 10, 12 and 14 days after cell culture. (2) In vivo repair: the hospital stay and wound healing time in the observation group were significantly lower than those in the control group (P < 0.05), and at the final follow-up, the postoperative recovery effect was significantly higher in the observation group than the control group (P < 0.05). The titanium meshes were fixed firmly in the two groups, with no floating, infection and exposure. These results show that the titanium mesh with gradient bioactive coating has good biocompatibility and osteoinduction capacity.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Huang Jun-hong, Ye Dang-hua, Gui Zhi-yong, Tan Zhan-guo, Meng Yu-li. Biological properties of gradient bioactive coatings on titanium surface in the skull repair[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(12): 1772-1778.

Figures/Tables 6

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