Allogeneic bone grafting strengthens the internal fixation of proximal humeral fractures in high-risk groups

doi:10.3969/j.issn.2095-4344.2016.12.014

Abstract

Abstract:

BACKGROUND: Numerous studies have focused on the clinical efficacy of allogeneic bone graft and humeral head replacement for the treatment of proximal humeral fractures, but their comparative studies are rarely reported.
OBJECTIVE: To investigate the effect of allogeneic bone grafting in the treatment of proximal humeral fractures in the high risk group.
METHODS: Clinical data of 120 cases of proximal humeral fractures aged ≥ 60 years were retrospectively analyzed. Sixty of the 120 cases underwent allogeneic bone grafting combined with locking plate fixation as experimental group, and the other 60 cases were subjected to semi-shoulder joint replacement as control group. All patients were followed up for 8-24 months. Fracture healing, collodiaphyseal angle, humeral head height and shoulder joint function were observed and measured.
RESULTS AND CONCLUSION: During the postoperative 8-24 months, all the fractures were healed by first intention, and there were no rejection reactions, large/small nodules, humeral head displacement, necrosis, and screw loosening. Loss of the humeral head height at the last follow-up and the active flexion angle of the shoulder at postoperative 12 weeks were significantly higher in the experimental group than the control group (P < 0.05). Scores on forearm, shoulder and hand dysfunction were significantly lower in the experimental group than the control group (P < 0.05). However, no significant difference was observed in the collodiaphyseal angle and SF-36 scores between the two groups. These finding indicate that allogeneic bone grafting can strength the internal fixation of proximal humeral fractures in the high-risk group, and improve patient’s upper limb function.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Su Zhi-hui, Lu Hou-gen, Liu Jun,Zou Li-xue, Hu Wei. Allogeneic bone grafting strengthens the internal fixation of proximal humeral fractures in high-risk groups[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(12): 1766-1771.

Figures/Tables 3

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