Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (12): 1697-1703.doi: 10.3969/j.issn.2095-4344.2016.12.004

Previous Articles     Next Articles

Degradation and compatibility of cuttlebone/racemic polylactic acid composite artificial bone in animals

Qin Guang-bing1,2, Xiao Ying1, Wang Wei2, Xiao Rong-chi1, Ou Jun3   

  1. 1Department of Spinal Surgery, Affiliated Hospital of Guilin Medical University, Guilin 541000, Guangxi Zhuang Autonomous Region, China; 2Guilin Medical University, Guilin 541000, Guangxi Zhuang Autonomous Region, China; 3Guilin University of Technology, Guilin 541000, Guangxi Zhuang Autonomous Region, China
  • Received:2016-01-10 Online:2016-03-18 Published:2016-03-18
  • Contact: Xiao Ying, Associate chief physician, Master’s supervisor, Department of Spinal Surgery, Affiliated Hospital of Guilin Medical University, Guilin 541000, Guangxi Zhuang Autonomous Region, China
  • About author:Qin Guang-bing, Studying for master’s degree, Department of Spinal Surgery, Affiliated Hospital of Guilin Medical University, Guilin 541000, Guangxi Zhuang Autonomous Region, China; Guilin Medical University, Guilin 541000, Guangxi Zhuang Autonomous Region, China

PDF

405

Abstract:

BACKGROUND: Cuttlebone/racemic polylactic acid composite artificial bone has been prepared in the previous studies to improve the incomplete degradation of cuttlebone.
OBJECTIVE: To observe the degradation and biocompatibility of cuttlebone/racemic polylactic acid composite artificial bone in animals.
METHODS: Thirty healthy New Zealand white rabbits were randomly divided into four groups. Models of right radial defects were prepared in rabbits, and model rabbits were subjected to implantation of cuttlebone/racemic polylactic acid composite artificial bone into the defects and muscular sac between the radial lateralis muscle and rectus (experimental group), implantation of cuttlebone into the defects and muscular sac between the radial lateralis muscle and rectus (control group 1), implantation of racemic polylactic acid into the defects and muscular sac between the radial lateralis muscle and rectus (control group 2), or no treatment (blank control group), respectively. At 2, 4, 8 weeks after operation, X-ray and histological examinations were performed in the four groups.
RESULTS AND CONCLUSION: (1) Compared with the other three groups, the bone mineral density of the experimental group was significantly higher at 4 and 8 weeks after material implantation into the defects (P < 0.05), and moreover, the bone mineral apposition rate of the experimental group was significantly higher at different time after operation (P < 0.05). At 8 weeks after operation, the bone tissues in the experimental group grew from the both ends to the center to form multiple bone island-like structures, with less residual materials, and the marrow cavity and implanting material were in a traffic manner; in the control group 1, there were many residual materials, and no intercommunication was found between the marrow cavity and implant material. (2) At 2 weeks after material implantation into the muscle capsule, there were more inflammatory cells, but the inflammation relieved at 4 weeks and disappeared basically at 8 weeks, and the material was degraded partially. These findings indicate that the cuttlebone/racemic polylactic acid composite artificial bone is a kind of good bone substitute material that has good biocompatibility and degradability.
 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程