Research advancement of calcium phosphate and calcium sulfate scaffolds in bone tissue engineering

doi:10.3969/j.issn.2095-4344.2016.08.021

Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (8): 1203-1209.doi: 10.3969/j.issn.2095-4344.2016.08.021

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Research advancement of calcium phosphate and calcium sulfate scaffolds in bone tissue engineering

Zhang Zhi-da¹, Jiang Xiao-bing², Shen Geng-yang¹, Ren Hui¹, Yang Zhi-dong², Cui Jian-chao², Chen Kang², Tang Jing-jing², Mo Ling², Lin Shun-xin¹, Liang De²

¹the First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China; ²the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China

Received:2015-11-25 Online:2016-02-19 Published:2016-02-19
Contact: Liang De, Chief physician, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
About author:Zhang Zhi-da, Studying for master’s degree, the First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
Supported by:
the National Natural Science Foundation of China, No. 81503591; the Scientific Research Project of Science and Technology Department of Guangdong Province & Guangdong Provincial Academy of Traditional Chinese Medicine, No. 2014A020221021; the Natural Science Foundation of Guangdong Province, No. 2014A030310082; the Discipline Construction Foundation of Guangdong Provincial Education Department, No. 2013LYM-0012; the Excellent Youth Scholar Foundation of Guangzhou University of Chinese Medicine, No. KAB110133K04; the Youbo Paper Culture Project of the First Clinical College of Guangzhou University of Chinese Medicine, No. YB201501

Abstract

Abstract:

BACKGROUND: It is a hotspot that calcium phosphate and calcium sulphate as the main ingredients are combined with one or more other materials to improve or increase the performance of bone tissue engineering scaffolds.
OBJECTIVE: To introduce the research advance of these two kinds of scaffolds in bone tissue engineering.
METHODS: The articles related to the bone tissue engineering published during January 2000 to June 2015 were retrieved from CNKI and PubMed databases by computer. The key words were “bone tissue engineering, scaffold, calcium phosphate, calcium sulphate, vascularization” in Chinese and English, respectively.
ESULTS AND CONCLUSION: Calcium phosphate and calcium sulfate are characterized as having good biocompatibility, biodegradability, osteoconductivity and complete bone substitutability. However, single use of calcium phosphate or calcium sulfate scaffold has certain disadvantages, both of which are difficult to fully meet the requirements of the bone defect repair. Improvement can be acquired in the mechanical strength, injectability and biodegradability, as well as drug-loading and pro-angiogenesis of the scaffold in combination with other materials. In the basal and clinical research, we should explore and develop ideal scaffolds in on the basis of therapeutic aim. However, most of the scaffold studies are still at the extracorporeal and animal experiment stage, and the comparative studies on composite scaffolds and optimal proportion of those composite scaffolds still need to be further investigated.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Zhang Zhi-da, Jiang Xiao-bing, Shen Geng-yang, Ren Hui, Yang Zhi-dong, Cui Jian-chao, Chen Kang, Tang Jing-jing, Mo Ling, Lin Shun-xin, Liang De. Research advancement of calcium phosphate and calcium sulfate scaffolds in bone tissue engineering[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(8): 1203-1209.

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Research advancement of calcium phosphate and calcium sulfate scaffolds in bone tissue engineering

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