Artificial ligament biomaterials repair cruciate ligament injury of the knee joint: problems and prospects

doi:10.3969/j.issn.2095-4344.2016.08.020

Abstract

Abstract:

BACKGROUND: Related studies have confirmed that the experimental results and short-term clinical outcomes of artificial ligaments are satisfactory that the artificial ligaments can restore the stability of knee joint as soon as possible and ensure motor function.
OBJECTIVE: To summarize the basic and clinical research progress of artificial ligaments.
METHODS: The articles regarding artificial ligaments in repair of knee joint cruciate ligament injury were retrieved from Wanfang database, CNKI and PubMed database during 1985 to 2015 by computer. The keywords were “cruciate ligament injuries, artificial ligament, biological materials” in Chinese and English, respectively.
RESULTS AND CONCLUSION: Compared with autologous and allogenic ligaments, artificial ligament has good mechanical properties, and can get sufficient tensile strength and joint stability immediately after implantation, so as to ensure the cruciate ligament reconstruction of the knee joint. Artificial ligament technology has experienced carbon fiber ligament, polyester material and stent artificial ligaments. As a new type of polyester artificial ligament, LARS artificial ligament shows a good biocompatibility, on which, cells can adhere, proliferate and differentiate well. However, the controversies over the use of artificial ligament still exist, and its long-term clinical effects still need further observation. Further researches regarding the material selection, shape bionic design, weaving and surgical techniques of artificial ligaments are still further needed.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Hou Li-gang, Yang Jian-yi. Artificial ligament biomaterials repair cruciate ligament injury of the knee joint: problems and prospects[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(8): 1196-1202.

References

[1] Liden M,Ejerhed L,Semert N,et al.Patellar tendon or semitendis nosus tendon autografts for anterior cruciate ligament reconstractior：a prospective，randomized study with a 72 year follows up.Am J Sports Med. 2007; 35 (5): 740-748.

[2] Nau T, Lavoie P,Duval N. A new generation of artificial ligaments in reconstruction of the anterior cruciate ligament. Two year follow up of a randomized trial. J Bone Joint Surg Br.2002；84(3):356-360.

[3] Zantop T,Petersen W,Sekiya JK,et al.Anterior erueiate ligament anatomy and function relating to anatomical reconstruction.Knee Surg Spots Traumatol Arthrosc. 2006;14(10):982-992.

[4] Gao K,Chen S,Wang L,et al.Anterior cruciate ligament reconstruction with LARS artificial ligament：a multicenter study with 3- to 5-year follow-up. Arthroscopy. 2010; 26: 515-523.

[5] Hamido F,Misfer AK,Al Harran H,et al.The use of the LARS artificial ligament to augment a short or undersized ACL hamstrings tendon graft.Knee. 2011; 18:373-378.

[6] Sherman OH,Banffy MB.Anterior cruciate ligament reconstruction: which graft is best. Arthrocopy. 2004; 20(9):974-980.

[7] Mascarenhas R,MacDonald PB.Anterior cruciate ligament reconstruction：a look at prosthetics--past，present and possible future.Mcgill J Med. 2008;11: 29-37.

[8] Trieb K,Blahovec H,Brand G,et al.In vivo and in vitro cellular in growth into a new generation of artificial ligaments.Eur Surg Res.2004;36(3):148-151.

[9] Ventura A,erzaghi C,Legnani C,et al. Synthetic grafts for anterior cruciate ligament rupture：19-year outcome study. Knee.2010;17:108-113.

[10] Lavoie P,Fletcher J,Duval N. Patient satisfaction needs as related to knee stability and objective findings after ACL reconstruction using the LARS artificial ligament. Knee. 2000;7:157-163.

[11] Lavoie P,Fletcher J,Duval N.Patient satisfaction needs as related to knee stability and objective findings after ACL reconstruction using the LARS artificial ligament. Knee. 2000;7:157-163.

[12] Liu ZT,Zhang XL,Jiang Y,et al. Four-strand hamstring tendon autograft versus LARS artificial ligament for anterior cruciate ligament reconstruction.Int Orthop. 2010;34:45-49.

[13] Malinin TI,Levitt RL,Bashore C,et al.A study of retrievedallografts used to replace anterior erueiate ligaments.Arthroscopy.2002;18:163-170.

[14] Wang K,Zhu L,Cai D,et al.Artificial biological ligament：its making，testing，and experimental study on animals. Microsurgery.2008;28:44-53.

[15] Salmon LJ,Russell VJ,Refshauge K,et al.Long-term outcome of endoscopic anterior cruciate ligament reconstruction withpatellar tendon autograft: minimum 13-year review. Am J Sports Med. 2006;34(5):721-732.

[16] Wang CJ,Chan YS,Weng LH,et al.Comparison of autogenous and allogenous posterior cruciate ligament reconstructions of the knee.Injury. 2004;35(12): 1279-1285.

[17] Wang CJ,Chan YS,Weng LH,et al.Comparison of autogenous and allogenous posterior cruciate ligament reconstructions of the knee.Injury. 2004;35(12): 1279-1285.

[18] Petrigliano FA,McAllister DR,Wu BM.Tissue engineering for anterior cruciate ligament reconstruction: a review of current strategies. Arthroscopy. 2006;22:441-451.

[19] Marder RA,Swanson TV,Sharkey NA,et al.Effects of partial patellectomy and reattachment of the patellar tendon onpatellofemoral contact areas and pressures. J Bone Joint Surg Am.993;75(1)35-45.

[20] Lohmander LS,Englund PM,Dahl LL,et al.The long-term consequence of anterior cruciate ligament and meniscus injuries：osteoarthritis.Am J Sports Med. 2007; 35(10): 1756-1769.

[21] Salmon LJ, Russell VJ, Refshauge K, et al. Long-term outcome of endoscopic anterior cruciate ligament reconstruction withpatellar tendon autograft: minimum 13-year review. Am J Sports Med. 2006;34(5):721-732.

[22] Shino K,Kimura T,Hirose H,et al. Reconstruction of the anterior cruciate ligament by allogeneic tendon graft. An operation for chronic ligamentous insufficiency. J Bone Joint Surg Br.1986;68(5):739-746.

[23] Friss EA,Cooke FW,McQueen DA,et al.Effect of bone block removal and patellar prosthesis on stresses in the humanpatella. Am J Sports Med. 1994;22(6):696-701.

[24] 高勇.PRP复合蚕丝人工韧带重建兔前交叉韧带的实验研究[D].山东:泰山医学院, 2014.1-55.

[25] 齐志明,王立德,于利,等.关节镜下人工韧带重建前交叉韧带的临床初步体会[J].中国微创外科杂志, 2005,5(5): 364-366.

[26] Zaffagnini S,Muccioli GM,Chatrath V,et al.Histological and ultrastructural evaluation of Leeds-Keio ligament 20 years after implant：a case report. Knee Surg Sports Traumatol Arthrosc.2008;16(11):1026-1029.

[27] Marder RA,Swanson TV,Sharkey NA,et al.Effects of partial patellectomy and reattachment of the patellar tendon onpatellofemoral contact areas and pressures. J Bone Joint Surg Am.1993,75(1):35-45.

[28] 饶天健,金跃辉,慕小瑜,等.重建韧带的新材料聚对苯二甲酸乙二酯复合毡型人工韧带研究[J].上海医学, 2006, 29 (7): 469-472.

[29] Frank CB, Jackson DW.The science of reconstruction of the anterior cruciate ligament. J Bone Joint Surg Am. 1997; 79(10):1556-1576.

[30] Miller MD, Fu FH. Arthroscopic allograft anterior cruciate ligament resconstruction. Optech Sorts Med. 1995;3:148-156.

[31] 张弛.纤维连接蛋白表面修饰对促进新型聚酯材料人工韧带生物相容性的研究[D].上海:上海交通大学, 2007:1-57.

[32] 张弛,蒋垚.纤维连接蛋白表面修饰对促进新型PET材料人工韧带(LARS)细胞黏附的实验研究[J].生物骨科材料与临床研究, 2009,6(5):16-20.

[33] Ibrahim SA,Ghafar S,Salah M,et al. Surgical management of traumatic knee dislocation with posterolateral corner injury. Arthroscopy. 2013;29(4):733-741.

[34] Friss EA,Cooke FW,McQueen DA,et al. Effect of bone block removal and patellar prosthesis on stresses in the humanpatella.Am J Sports Med. 1994;22(6):696-701.

[35] Chen CP,Lin YM,Chiu YC,et al.Outcomes of arthroscopic double-bundle PCL reconstruction using the LARS artificial ligament. Orthopedics. 2012;35(6):800-806.

[36] 王昆,朱蕾,金文涛,等.生物型人工韧带的体外检测和体内组织相容性的实验研究[J].中国病理生理杂志, 2010, 26(12): 2394-2399.

[37] 吴惠英,左保齐.医用支架型前交叉韧带的设计[J].针织工业, 2012,40(12):17-19.

[38] 王洪,严力军,杨述华,等.蚕丝支架韧带材料的机械强度和体外降解性[J].中国组织工程研究与临床康复, 2008, 12(19): 3774-3770.

[39] 刘庆鹏,于连祥,丁晓琳,等.BMP加强型蚕丝人工韧带重建兔ACL的实验研究[J].中国矫形外科杂志, 2013,21(8): 799-807.

[40] 袁拥军,何国础,岑建平.先进人工韧带加强系统人工韧带与自体骨髌腱-骨重建膝前交叉韧带的早期临床疗效比较[J].上海医学, 2009,32(7):598-601.

[41] Osanai T,Tsuchiya T,Sugawara M.Histologic examination of Leeds-Keio artificial ligament implanted on the surface of a tumor endoprosthesis.J Arthroplasty. 2009;24(1):159.

[42] 袁拥军,何国础,岑建平,等.先进人工韧带加强系统人工韧带与自体骨-髌腱-骨重建膝前交叉韧带的早期临床疗效比较[J].上海医学,2009,32(7):598-601.

[43] 袁拥军,何国础,岑建平,等.关节镜下先进人工韧带加强系统人工韧带重建膝关节后交叉韧带[J].上海医学, 2010, 33(3): 260-264.

[44] 李利南,张卫国,王立德,等.韧带增强重建系统人工韧带重建前交叉韧带中期疗效分析[J].中华创伤杂志, 2013, 29(8): 756-761.

[45] 吴宇黎,吴海山,李晓华,等.LARS人工韧带在前交叉韧带重建中的作用[J].实用骨科杂志,2007,13(1):4-6.

[46] 范钦波,范继峰.关节镜下先进人工韧带加强系统和四股自体半腱肌腱重建前交叉韧带的疗效比较[J].中国修复重建外科杂志, 2008,22(6):676-679.

[47] 陈世益,洪国威,陈疾忤,等.LARS人工韧带与自体腘绳肌腱重建前交叉韧带早期临床疗效比较[J].中国运动医学杂志, 2007,26(5):530-533.

[48] 康一凡,王谦,汪滋民.关节镜下LARS人工韧带重建后交叉韧带及有限切开重建外侧副韧带[J].中国骨与关节损伤杂志, 2008,23(3):23-25.

[49] 徐又佳,董启榕,周海斌,等.关节镜下LARS人工韧带重建后交叉韧带[J].中国修复重建外科杂志,2008,37(10): 1184-1188.

[50] 栾冲,张才龙,孙康,等.关节镜下LARS人工韧带与γ射线照射的同种异体肌腱重建前交叉韧带早期临床疗效比较[J].中国矫形外科杂志,2010,18(10):808-811.

[51] Ghalayini SR,Helm AT,Bonshahi AY,et al. Arthroscopic anterior cruciate ligament surgery：results of autogenous patellar tendon graft versus the Leeds-Keio synthetic graft five year follow-up of a prospective randomised controlled trial. Knee. 2010;17(5):334-339.