Autologous bone marrow mesenchymal stem cells combined with hydroxyapatite/ tricalcium phosphate complex in the spinal fusion

doi:10.3969/j.issn.2095-4344.2016.08.002

Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (8): 1075-1080.doi: 10.3969/j.issn.2095-4344.2016.08.002

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Autologous bone marrow mesenchymal stem cells combined with hydroxyapatite/ tricalcium phosphate complex in the spinal fusion

Yan Wei¹, Yang Li¹, Ling Mei², Gan Jia-liang³

¹Anyang District Hospital, Anyang 455001, Henan Province, China; ²First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453000, Henan Province, China; ³Liwan Hospital of Guangzhou Medical College, Guangzhou 510170, Guangdong Province, China

Received:2016-01-03 Online:2016-02-19 Published:2016-02-19
Contact: Gan Jia-liang, Master, Liwan Hospital of Guangzhou Medical College, Guangzhou 510170, Guangdong Province, China
About author:Yan Wei, Associate chief physician, Anyang District Hospital, Anyang 455001, Henan Province, China
Supported by:
the Medicine and Health Scientific Projects of Guangzhou City, No. 201102A212002, 20142A010022; the Scientific Research Plan of Liwan District of Guangzhou, No. 20124313106-2

Abstract

Abstract:

BACKGROUND: The use of bone graft materials can promote bone fusion and enhance the stability of the spine during the spinal fusion.
OBJECTIVE: To investigate the effect of autologous bone marrow mesenchymal stem cells with hydroxyapatite/ tricalcium phosphate in the spinal fusion.
METHODS: A retrospective analysis of clinical data of 64 patients with spinal fusion was carried out, and these patients were divided into two groups (n=32 per group): control group undergoing autogenous iliac bone grafting and observation group undergoing autologous bone marrow mesenchymal stem cells combined with hydroxyapatite/tricalcium phosphate. All patients were followed up for 12 months, and their recovery conditions about low back pain, spinal fusion and vertebral reset were assessed.
RESULTS AND CONCLUSION: The low-back outcome scale scores and excellent rate, Lenke grading and Cobb angle had insignificant differences between the two groups after treatment (P > 0.05). No infection, inflammation and skin irritation occurred in the two groups. The coagulation function, renal function and inflammatory factor levels were at normal levels in all the patients, and there was no difference between the two groups (P > 0.05). These findings indicate that autologous bone marrow mesenchymal stem cells combined with hydroxyapatite/tricalcium phosphate can achieve clinical outcomes equivalent to the autologous iliac bone grafting.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Yan Wei, Yang Li, Ling Mei, Gan Jia-liang. Autologous bone marrow mesenchymal stem cells combined with hydroxyapatite/ tricalcium phosphate complex in the spinal fusion[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(8): 1075-1080.

Figures/Tables 5

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Autologous bone marrow mesenchymal stem cells combined with hydroxyapatite/ tricalcium phosphate complex in the spinal fusion

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