Autogenous bone, recombinant human bone morphogenetic protein 2 composite bone or allogeneic bone in rabbit lumbar spinal fusion

doi:10.3969/j.issn.2095-4344.2016.03.002

Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (3): 314-318.doi: 10.3969/j.issn.2095-4344.2016.03.002

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Autogenous bone, recombinant human bone morphogenetic protein 2 composite bone or allogeneic bone in rabbit lumbar spinal fusion

Zhang Ke, Peng Qiang

Department of Pediatric Surgery, First Affiliated Hospital of Sichuan Medical University, Luzhou 646000, Sichuan Province, China

Received:2015-11-15 Online:2016-01-15 Published:2016-01-15
Contact: Peng Qiang, M.D., Professor, Department of Pediatric Surgery, First Affiliated Hospital of Sichuan Medical University, Luzhou 646000, Sichuan Province, China
About author:Zhang Ke, Studying for master’s degree, Physician, Department of Pediatric Surgery, First Affiliated Hospital of Sichuan Medical University, Luzhou 646000, Sichuan Province, China
Supported by:
a grant from Sichuan Health Department, No. 140049; the National Natural Science Foundation of China, No. 81372110

Abstract

Abstract:

BACKGROUND: Recombinant human bone morphogenetic protein 2 (rhBMP2) can effectively promote new
bone formation and fracture healing, but its specific application in the lumbar spinal fusion remains controversial.
OBJECTIVE: To study the effect of autogenous bone, rhBMP2 composite bone or allogeneic bone on the lumbar spinal fusion of rabbits.
METHODS: Forty-five New Zealand white rabbits were enrolled to make intertransverse lumbar interbody fusion models and then randomly subjected to autogenous iliac bone, rhBMP2 composite bone or allogeneic iliac bone via L5-L6 intertransverse process, respectively. Then, the rats were sacrificed under anesthesia at 8 weeks after operation to observe the lumbar fusion.
RESULTS AND CONCLUSION: Compared with the allogeneic iliac bone group, the fusion rates, tensile strength ratio of L5-6/L4-5, and percentage of new bone tissues were increased more significantly in the other two groups (P < 0.05), and moreover, there was no difference between the autogenous iliac bone and rhBMP2 composite bone groups. These findings indicate that the autogenous iliac bone and rhBMP2 composite bone have similar fusion effects, both of which are superior to the allogeneic bone.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Zhang Ke, Peng Qiang. Autogenous bone, recombinant human bone morphogenetic protein 2 composite bone or allogeneic bone in rabbit lumbar spinal fusion[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(3): 314-318.

Figures/Tables 3

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Autogenous bone, recombinant human bone morphogenetic protein 2 composite bone or allogeneic bone in rabbit lumbar spinal fusion

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