Experimental progress of signal transduction pathways in knee osteoarthritis

doi:10.3969/j.issn.2095-4344.2016.02.020

Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (2): 267-272.doi: 10.3969/j.issn.2095-4344.2016.02.020

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Experimental progress of signal transduction pathways in knee osteoarthritis

Wang Hua-min^{1, 2}, Mi Yi-qun^{1, 2}, Gang Jia-hong²

¹Graduate School of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; ²Department of Acupuncture & Moxibustion Tuina Traumatology, the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China

Received:2015-11-03 Online:2016-01-08 Published:2016-01-08
Contact: Mi Yi-qun, Chief physician, Master’s supervisor, Graduate School of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Department of Acupuncture & Moxibustion Tuina Traumatology, the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China
About author:Wang Hua-min, Studying for master’s degree, Graduate School of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Department of Acupuncture & Moxibustion Tuina Traumatology, the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China
Supported by:
the Three-Year Action Plan Project of Shanghai Traditional Chinese Medicine of Shanghai Municipal Commission of Health and Family Planning and the Office of Chinese Medicine Development, No. zy3-pcpy-3-1018

Abstract

Abstract:

BACKGROUND: Studies have shown that signaling pathway plays an important role in the pathogenesis of knee osteoarthritis.
OBJECTIVE: To elaborate the experimental progress of signal transduction pathway in knee osteoarthritis
METHODS: A computer-based retrieval of PubMed, CNKI, VIP and Wanfang databases was performed to find the relevant literatures concerning experimental studies of signaling pathway in knee osteoarthritis. All data were primarily screened to exclude repeated and irrelevant articles. Articles about association between knee osteoarthritis and signal pathway were included.

RESULTS AND CONCLUSION: A total of 51 articles were collected, including 20 in Chinese and 31 in English. It is concluded that the signal transduction pathway related to knee osteoarthritis is mainly concentrated in the two aspects: the proliferation of chondrocytes and the apoptosis of chondrocytes. The signal transduction pathways related to the proliferation of chondrocytes mainly include Notch signaling pathway and Wnt signaling pathway. SDF-1/CXCR4 signaling pathway, TLR4 signaling pathway, and MAPKs signaling pathway are associated with apoptosis in chondrocytes. Hippo-YAP signaling pathway and ERK1/2 signaling pathway have a double role in the regulation of proliferation and apoptosis of chondrocytes.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Wang Hua-min, Mi Yi-qun, Gang Jia-hong. Experimental progress of signal transduction pathways in knee osteoarthritis[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(2): 267-272.

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Experimental progress of signal transduction pathways in knee osteoarthritis

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