Chinese Journal of Tissue Engineering Research

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Research progress in preconditioning strategy promoting mesenchymal stem cell homing

Wang Guo-ren, Bai Zhi-ming   

  1. 1Department of Urology,Affiliated Haikou Hospital, Xiangya School of Medicine Central South University, Haikou 570208, Hainan Province,China
  • Received:2013-08-16 Online:2019-03-28 Published:2019-03-28
  • Supported by:

    the Natural Science Foundation of Hainan Province, No. 811151

Abstract:

Homing is the initial and key procedure of stem cells-based tissue restoration.Current studies have shown that the inability to recruit these mesenchymal stromal cells to target tissue with high efficiency remains a significant barrier to tissue restoration.Preconditioning strategy provides a new sight in promoting homing of stem cells.Altered local microenvironment via tissue preconditioning and enhanced expression of surface receptors or factors via cellular preconditioning are both capable of enhancing stem cell homing,thus facilitates restoration of impaired tissue.