Biocompatibility of hydroxyapatite modified titanium skirt for keratoprosthesis

doi:10.3969/j.issn.2095-4344.2013.51.015

Abstract

Abstract:

BACKGROUND: Titanium implants as a safe biological material have been used to produce the artificial Russian titanium cornea, but complications still exist, including artificial cornea shift, leakage, corneal tissue melting and artificial cornea discharge.
OBJECTIVE: To evaluate in vivo biocompatibility of hydroxyapatite modified titanium skirt for keratoprosthesis in alkali burn cornea.
METHODS: A total of 30 alkali burned New Zealand white rabbit corneas were divided into three group groups. Hydroxyapatite modified titanium skirt (experimental group) and titanium skirt (control group) were respectively inserted into the corneal stroma of rabbits. In the blank control group, only a lamellar corneal incision was made.
RESULTS AND CONCLUSION: All skirts were stable without necrosis, melting and exclusion during the observation period. The number of inflammatory cells in the experimental and control groups was significantly higher than that in the blank control group at 2 and 8 weeks postoperatively (P < 0.05), but there was no difference in inflammatory cell infiltration among different groups by the 16th week. The number of corneal fibroblasts increased significantly in the experimental group compared with the control and blank control group after 2, 8, 16 weeks (P < 0.05). The extracellular matrix deposited on the surface of hydroxyapatite modified titanium skirt was denser and tighter than that on the surface of titanium skirt. It indicates that hydroxyapatite modified titanium skirt for keratoprosthesis can promote the

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

interfacial biointegration of skirt and host cornea.

Key words: biocompatible materials, hydroxyapatites, titanium, cornea, stents

CLC Number:

R318

Ma Xiao, Shi Hong, Huang Yi-fei, Huang Jing-xiang, Cui Fu-zhai . Biocompatibility of hydroxyapatite modified titanium skirt for keratoprosthesis[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(51): 8875-8880.

Figures/Tables 8

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