Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (51): 9558-9562.doi: 10.3969/j.issn.2095-4344.2012.51.011
Previous Articles Next Articles
Cui Xu, Ma Yuan-zheng, Li Da-wei, Xue Hai-bin
Online:
Published:
Abstract:
BACKGROUND: The degradation rate and strength of poly (lactic-co-glycolic acid) (PLGA) can be regulated by the addition of β-tricalcium phosphate (TCP), and the load of bone morphogenetic protein (BMP) can promote the osteoinductive capacity. OBJECTIVE: To test the effect of slow-release PLGA/β-TCP/isoniazid (INH)/BMP material on the repair of segmental radial defects in rabbits. METHODS: Forty New Zealand rabbits were collected and a rabbit model of 12-mm left radial defects was established. The rabbits were randomly divided into four groups: group 1, group 2, group 3 and group 4. The former three groups were implanted PLGA/β-TCP material, PLGA/β-TCP/INH material and PLGA/β-TCP/INH / BMP material, respectively. The group 4 served as the blank control group (without implants). RESULTS AND CONCLUSION: At week 12 after treatment, radial defects in the former three groups were all repaired well, and the PLGA/β-TCP/INH /BMP group obtained the best results (P < 0.05). The blank control group failed to restore radial defects. These results suggest that the slow-release PLGA/β-TCP/INH/BMP material can effectively repair the 12-mm long radial defects in rabbits.
Cui Xu, Ma Yuan-zheng, Li Da-wei, Xue Hai-bin. Bone morphogenic protein slow-release compound materials for repair of radial defects in rabbits[J]. Chinese Journal of Tissue Engineering Research, 2012, 16(51): 9558-9562.
0 / / Recommend
Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks
URL: https://www.cjter.com/EN/10.3969/j.issn.2095-4344.2012.51.011
https://www.cjter.com/EN/Y2012/V16/I51/9558