Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (43): 8111-8116.doi: 10.3969/j.issn.2095-4344.2012.43.027

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Development of arginine-glycine-aspartic acid peptide analogues in endothelial targeted therapy of neovascularization

Zhou Yan-fang1, 2, Deng Yu-bin2   

  1. 1Department of Pathophysiology, Guangdong Medical College, Dongguan 523808, Guangdong Province, China
    2Department of Pathophysiology, Medical School of Sun Yat-sen University, Zhongshan 510080, Guangdong Province, China
  • Received:2011-12-05 Revised:2011-12-28 Online:2012-10-21 Published:2012-10-21
  • Contact: Deng Yu-bin, Doctor, Professor, Department of Pathophysiology, Medical School of Sun Yat-sen University, Zhongshan 510080, Guangdong Province, China dengyub@ mail.sysu.edu.cn
  • About author:Zhou Yan-fang☆, Doctor, Associate professor, Department of Pathophysiology, Guangdong Medical College, Dongguan 523808, Guangdong Province, China; Department of Pathophysiology, Medical School of Sun Yat-sen University, Zhongshan 510080, Guangdong Province, China Fangfang772003@ 163.com

Abstract:

BACKGROUND: Vascular endothelium plays an important role in ischemia, thrombosis, inflammation, edema, oxidative stress and other pathological damages. It is critical to select the specific endothelial target for drug intervention.
OBJECTIVE: To analyze and summarize the researches about arginine-glycine-aspartic acid (RGD) peptide and its analogues used as specific endothelial targets in recent years.
METHODS: A computer-based online search of related articles published from January 1998 to December 2011 was performed in PubMed database using the key words of “RGD, integrin, targeted therapy”. The documents related to neovascularization were included. The literatures of irrelevant purpose and repetitive content were excluded. Finally, 42 literatures were chosen to summarize.
RESULTS AND CONCLUSION: Integrin αvβ3 is the specific target in pathological damage of endothelial cells and neovascularization which is involved in the migration, proliferation and differentiation of endothelial cells. As the interacting recognition sites of integrin and its ligand, RGD peptide can be combined with integrin αvβ3 with high expression in tumor or pathological angiogenesis, and can mediate the interactions between cell-extracellular matrix and cell and cells. RGD peptide plays an important role in angiogenesis imaging, targeted drug delivery and carrier material modification.

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