Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (43): 8061-8066.doi: 10.3969/j.issn.2095-4344.2012.43.018

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In vivo test of a magnetic suspension centrifugal ventricular assist device and its hemocompatibility

Li Hai-yang1, Wu Guang-hui2, Wang Cheng-de3, Lin Chang-yan2, Hou Xiao-tong1, Chen Chen4, Yang Peng4, Qu Wen-bo4, Liu Xiu-jian2, Xu Chuang-ye2   

  1. 1Affiliated Beijing An Zhen Hospital of Capital Medical University, Beijing 100029, China
    2Beijing Heart, Lung & Blood Vessel Disease Research Institute, Affiliated Beijing An Zhen Hospital of Capital Medical University, Beijing 100029, China
    3Weifang Yidu Central Hospital, Weifang 262500, Shandong Province, China
    4China Heart Biomedical Incorporation, Suzhou 215125, Jiangsu Province, China
  • Received:2012-01-21 Revised:2012-03-14 Online:2012-10-21 Published:2012-10-21
  • Contact: Lin Chang-yan, Professor, Beijing Heart, Lung & Blood Vessel Disease Research Institute, Affiliated Beijing An Zhen Hospital of Capital Medical University, Beijing 100029, China
  • About author:Li Hai-yang★, Master, Attending physician, Affiliated Beijing An Zhen Hospital of Capital Medical University, Beijing 100029, China assosiate@sina.com

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Abstract:

BACKGROUND: The unique apex intubation design of a magnetic suspension centrifugal ventricular assist device can finish left ventricular intubation with heart beating, which significantly shortens the operative time and avoids the harmful effects of cardiopulmonary bypass.
OBJECTIVE: To verify the in vivo reliability of the magnetic suspension centrifugal left ventricular assist device.
METHODS: The magnetic suspension centrifugal left ventricular assist device was implanted into the left ventricular apex of a healthy sheep with heart beating. The outflow graft of each device was anastomosed to the descending aorta. Hematologic, biochemical and blood clotting tests before and after surgery were performed on schedule. Data associated with pump function were collected continuously, and the end-organs were examined macroscopically and histopathologically.
RESULTS AND CONCLUSION: During the in vivo assisted 38 days, no mechanical wearing and the thrombus formation at inflow and outflow were observed inside the pump. Hematologic and biochemical test results were within the normal range. There were no significant complications in the sheep. Macroscopical and histopathological examination of the end organs revealed no evidence of ischemia or infarction. These findings suggest that the magnetic suspension centrifugal left ventricular assist device has good in vivo hemocompatibility and reliability.

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