Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (43): 8032-8036.doi: 10.3969/j.issn.2095-4344.2012.43.012

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Coralline hydroxyapatite combined with guided bone regeneration for repairing alveolar bone defects

Dai Xiao-wei1, Ruan Xiao-hui2, Nijiati·Tuerxun   

  1. 1Department of Stomatology, Xinjiang Medical University, Urumqi 830054, Xinjiang Uyghur Autonomous Region, China
    2Department of Stomatology, the Second Clinical Medical College of Xinjiang Medical University, Urumqi 830063, Xinjiang Uyghur Autonomous Region, China
  • Received:2012-01-31 Revised:2012-03-11 Online:2012-10-21 Published:2012-10-21
  • Contact: Nijiati·Tuerxun, Master, Associate chief physician, Master’s supervisor, Department of Stomatology, the Second Clinical Medical College of Xinjiang Medical University, Urumqi 830063, Xinjiang Uyghur Autonomous Region, China kqnijiat@126.com
  • About author:Dai Xiao-wei★, Studying for master’s degree, Physician, Department of Stomatology, Xinjiang Medical University, Urumqi 830054, Xinjiang Uyghur Autonomous Region, China dxwkq@sina.com

Abstract:

BACKGROUND: The coralline hydroxyapatite is take high quality natural narine biological as raw materials. It forms hydroxyapatite thin layer in coral skeleton, so it keeps natural coral distributed framework, thereby providing a good space for tissue growth.
OBJECTIVE: To investigate the clinical effect of coralline hydroxyapatite on guiding bone regeneration for the repair of alveolar bone defects.
METHODS: Forty-two patients with bone defects caused by mandibular first molar periodontitis were collected and randomly divided into experimental group and control group. Patients in the experimental group were treated with coralline hydroxyapatite combined with oral biofilm to fill and repair bone defects, and those in the control group were only treated with coralline hydroxyapatite.
RESULTS AND CONCLUSION: The patients were followed up for 12 months and the results showed that periodontal attachment loss was found in the two groups, besides, periodontal probing depth was improved obviously after treatment (P < 0.05). In addition, compared with the control group, periodontal attachment loss and periodontal probing depth in the experimental group were better (P < 0.05). Moreover, new bone formation density and bone mass of the experimental group were superior to those of the control group (P < 0.05). These results suggest that coralline hydroxyapatite combined with guided bone regeneration technique can have good effect on guiding bone regeneration and repair bone defects.

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