Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (43): 8027-8031.doi: 10.3969/j.issn.2095-4344.2012.43.011

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Porous tantalum scaffold compounded with synovium versus tricalcium phosphate compounded with synovium for repairing cartilage defects

Liu Ning, Qian Qi-rong, Xu Wei, Peng Jin-hui, Zhou Rong   

  1. Department of Bone Tumor, Shanghai Changzheng Hospital, Shanghai 200003, China
  • Received:2012-01-02 Revised:2012-02-20 Online:2012-10-21 Published:2012-10-21
  • Contact: Qian Qi-rong, Doctor, Associate professor, Department of Bone Tumor, Shanghai Changzheng Hospital, Shanghai 200003, China
  • About author:Liu Ning★, Studying for master’s degree, Physician, Department of Bone Tumor, Shanghai Changzheng Hospital, Shanghai 200003, China in88h@sina.com

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Abstract:

BACKGROUND: Early experiments have proved that synovium contains mesenchymal stem cells which can potentially form the cartilage or bone and differentiate into chondrocytes under property conditions.
OBJECTIVE: To compare the repair effect of porous tantalum combined with synovium and tricalcium phosphate combined with synovium on cartilage defects.
METHODS: Totally 24 female New Zealand rabbits were randomly divided into experimental group (a porous tantalum scaffold combined with synovium) and control group (a tricalcium phosphate scaffold combined with synovium). A model of cartilage defect in the knee joint was establishe, and then the two kinds of scaffolds were implanted. A piece of pretreated inverse synovium was covered on the surface of defects, and plaster fixation was performed for 2 weeks. The rabbits were executed under anesthesia at week 12. The gross observation of the synovium, joint fluid and femoral condylar cartilage, as well as the pathological features of the femoral condylar cartilage was observed. Improved Mankin score was obtained to evaluate the repair effect.
RESULTS AND CONCLUSION: In the experimental group, there was various synovial hyperplasia, and the surface of new cartilage was blue and white, and the margin was less smooth. Toluidine blue staining showed that chondrocytes arranged a little disorder. Resides, the number of chondrocytes was normal, moreover the porous tantalum scaffolds were fully filled with bone tissues, and the Mankin score was 7.35. In the control group, the surface of new cartilage was blue and white, and the margin was less smooth. Toluidine blue staining showed that chondrocytes arranged a little disorderly. The number of chondrocytes was normal. In addition, the tricalcium phosphate scaffolds were partly filled with bone, and the Mankin score was 7.43 (P > 0.05). These findings suggest that there is no significant difference between porous tantalum combined with synovium and tricalcium phosphate combined with synovium in repairing cartilage defects, but the fusion of porous tantalum scaffolds with surrounding bone tissues is superior to that of tricalcium phosphate.

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