Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (43): 8023-8026.doi: 10.3969/j.issn.2095-4344.2012.43.010

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Preparation and characterization of nano-silver slow-release chitosan/polyvinyl alcohol sponge wound dressings

Xu Wei-kang1,2,3, Wei Kun1,2,3, Zeng Xiao-feng1,2,3, Ling You1,2,3, Zhang Jie1,2,3, Wei Xin-miao1,2,3   

  1. 1School of Material Science and Engineering, South China University of Technology, Guangzhou 510640, Guangdong Province, China
    2National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, Guangdong Province , China
    3Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou 510006, Guangdong Province ,China
  • Received:2012-01-19 Revised:2012-03-12 Online:2012-10-21 Published:2012-10-21
  • Contact: Wei Kun Doctor, Professor, School of Material Science and Engineering, South China University of Technology, Guangzhou 510640, Guangdong Province, China; National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, Guangdong Province, China; Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou 510006, Guangdong Province ,China weikun@scut.edu.cn
  • About author:Xu Wei-kang★, Studying for master’s degree, School of Material Science and Engineering, South China University of Technology, Guangzhou 510640, Guangdong Province, China; National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, Guangdong Province, China; Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou 510006, Guangdong Province, China xuweikang@126.com

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Abstract:

BACKGROUND: The clinical treatment of traditional wound infection is mainly use antibiotic drugs dressings, but the long-term use can cause bacteria resistance. Meanwhile, nano wound dressings used in clinical application has poor biocompatibility and cannot be degraded, which should not be used for long-term coverage of wound.
OBJECTIVE: To prepare a wound dressing with antibacterial action and good biocompatibility, and to characterize and analysis its biological properties.
METHODS: Chitosan/polyvinyl alcohol sponge containing nano-silver/polyethyleneglycol was prepared by acetalization reaction. The material’s mechanical properties, surface topography, in vitro release, and antibacterial properties were detected.
RESULTS AND CONCLUSION: The particle diameter of nano-silver prepared was small and it had good disparity. The in vitro release studies showed that Ag nano-silver particles were able to release continuously and sterilize the bacterium. The Chitosan/polyvinyl alcohol sponge containing nano-silver/polyethyleneglycol had dense and uniform interspaces; the pores inside was interconnected, and had favorable moisture-adsorption rate, moisture-retention rate, and moderate air permeability rate. The moisture-adsorption rate and air permeability rate were increased with the content of polyvinyl alcohol 1799 increased, but the moisture-retention rate almost had no effects with the changes of the content of polyvinyl alcohol 1799. The material had a good bactericidal effect on the staphylococcus aureus, escherichia coli, candida albicans, pseudomonas aeruginosa and salmonella typhi. These findings suggest that the dressing not only possesses good physical properties and anti-microbial, but also its synthesis procedure is simple and low cost. Therefore, the developed material can be applied to new wound dressing.

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