Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (42): 7977-7980.doi: 10.3969/j.issn.2095-4344.2012.42.036

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Polymorphisms of interleukin-1 receptor antagonist gene in ankylosing spondylitis patients who are Han nationality from Hubei Province

You Hao1, Cheng Cui-nian1, Zhang Hui1, Li Jia-sen2, Li Yu-wan2, Hu Xiao-hong2, Hu Feng-ping2, Zhou Shi-li3, Gao Jin-song2   

  1. 1The Fifth Hospital of Wuhan, Wuhan 430050, Hubei Province, China
    2Changsha Medical College, Changsha 410219, Hunan Province, China
    3Jianghan University, Wuhan 430056, Hunan Province, China
  • Received:2012-02-10 Revised:2012-03-26 Online:2012-10-14 Published:2012-10-14
  • Contact: Gao Jin-song, Master, Associate professor, Changsha Medical College, Changsha 410219, Hunan Province, China gjs1968@126.com
  • About author:You Hao★, Master, Chief physician, Associate professor Master’s supervisor, the Fifth Hospital of Wuhan, Wuhan 430050, Hubei Province, China yourenyouyu2010@yahoo.cn

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Abstract:

BACKGROUND: Interleukin 1 (IL-1) gene cluster contains a major susceptibility locus for ankylosing spondylitis. Its polymorphisms are correlated with the susceptibility of ankylosing spondylitis. The study results are often different in different population.
OBJECTIVE: To analyze the correlation between polymorphism of IL-1 receptor antagonist (IL-1RN) gene and patients with ankylosing spondylitis. The patients are the population of Han nationality of Hubei Province in China.
METHODS: DNA samples were collected from 140 patients with ankylosing spondylitis and 130 healthy as controls. The IL-1RN VNTR polymorphisms were determined by PCR method. All patients are of Han nationality and lived in Hubei Province for three generations at least.
RESULTS AND CONCLUSION: Compared with the healthy controls, IL-1RN VNTR*2 allelic frequency in patients with ankylosing spondylitis was significant higher (P < 0.05).

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