Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (40): 7588-7595.doi: 10.3969/j.issn.2095-4344.2012.40.031

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Flap transplantation and immunoregulation

Wang Hai-han1, Wang Jia1, Long Teng-he2   

  1. 1Department of Orthopedics, 2Department of Radiology, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, Guangxi Zhuang Autonomous Region, China
  • Received:2012-06-15 Revised:2012-07-10 Online:2012-09-30 Published:2012-09-30
  • Contact: Long Teng-he, Associate chief physician, Department of Radiology, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, Guangxi Zhuang Autonomous Region, China longtenhe1965@yahoo.com.cn
  • About author:Wang Hai-han, Attending physician, Department of Orthopedics, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, Guangxi Zhuang Autonomous Region, China 949337723@qq.com

Abstract:

BACKGROUND: Skin lesions are very common, and flap transplantation is a kind of treatment method for skin lesions, and has been widely applied. Design reasonable flap transplantation and suppress the rejection after transplantation can improve the survival status of the transplanted flap.
OBJECTIVE: To research the immunoregulation mechanism and inhibitory factor after flap transplantation, and to provide reference information for the research of immunoregulation after flap transplantation.
METHODS: The Wanfang database was searched for the related articles on the immunoregulation after flap transplantation from 2002 to 2011 and the in-depth analysis was performed. The experimental data analysis was performed to analyze the feasibility of the establishment of flap transplantation models, the effect of nitric oxide and fibroblast growth factor on flap transplantation, as well as the microcirculation protection after flap transplantation, in order to indentify the influential factors of the survival of transplanted flap, and to regulate, extend the survival of the transplanted flap and improve the state of survival after flap transplantation.
RESULTS AND CONCLUSION: The rat model with flap transplantation is a good flap transplantation animal model, it can be used to establish the model with various flap transplantation, and can be used for the experimental research on the immunity and the microcirculation of flap transplantation. During the immunoregulation after flap transplantation, both nitric oxide and fibroblast growth factor has regulation effect on the immune response, while the propofol and papaverine hydrochloride substances play a important role in microcirculation protection after flap transplantation.

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