Abstract:

BACKGROUND: From 1906 until now, erythropoietin has been found in lots of tissues and organs, which cannot only promote proliferation and differentiation of red blood cells, but also prevent cell apoptosis and accelerate the formation of collagen and blood vessels.
OBJECTIVE: To review the research about erythropoietin promoting angiogenesis in many tissue and organs and to clarify the status of its effect on angiogenesis.
METHODS: A computer search of CNKI database (2005/2011), PubMed database (1988/2011) and FMJS database (2000/2011) was performed by the first author using “erythropoietin, angiogenesis” in Chinese and English as the key words, to retrieve articles about the effect of erythropoietin on angiogenesis. Finally, 33 articles were included in result analysis.
RESULTS AND CONCLUSION: Totally 45 articles were obtained by the preliminary check, the titles and abstracts and partial contents were screened, and 33 literatures meeting the inclusion criteria were summarized. The findings show that erythropoietin is a glycoprotein hormone secreted by the adult kidney and liver embryos. Erythropoietin can promote proliferation of endothelial progenitor cells and angiogenesis of the cardiovascular system, brain tissue, retina, uterus, tumor tissue, skin and so on, and has applied to the part of clinical treatment.