Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (37): 7015-7019.doi: 10.3969/j.issn.2095-4344.2012.37.034

Previous Articles     Next Articles

Effect of mitogen-activated protein kinases signaling pathway on osteoarthritis cartilage

Fan Su-fang1, Wang Wen-ya1, Zhang Liu2   

  1. 1Department of Pathology, Hebei United University, Tangshan 06300, Hebei Province, China
    2Department of Orthopedic Surgery, Affiliated Hospital of Hebei United University, Tangshan 06300, Hebei Province, China
  • Received:2012-01-04 Revised:2012-01-15 Online:2012-09-09 Published:2012-09-09
  • Contact: Wang Wen-ya, Master’s supervisor, Professor, Department of Pathology, Hebei United University, Tangshan 06300, Hebei Province, China wangwenya-3@126.com
  • About author:Fan Su-fang★, Studying for master’s degree, Department of Pathology, Hebei United University, Tangshan 06300, Hebei Province, China 964013115@qq.com

PDF

401

Abstract:

BACKGROUND: Articular cartilage degeneration is considered to be the main pathological change in osteoarthritis, and abnormal cartilage signal transduction is the key factor in articular cartilage degeneration.
OBJECTIVE: To review the updated progresses of mitogen-activated protein kinases (MAPK) signaling pathway and to further analyze the role of MAPKs pathway in osteoarthritis cartilage．
METHODS: First author searched literatures from CNKI and PubMed databases from 1990 to 2011, using the key words of “osteoarthritis, articular cartilage, ERK, JNK, P38, MAPK signaling pathway” in Chinese and English, respectively. Articles related to MAPK signaling pathway and the effect of MAPK signaling pathway on osteoarthritis cartilage were included. Reproducibility articles were excluded.
RESULTS AND CONCLUSION: Of 120 articles retrieved, 32 were selected according to the inclusive and exclusive criteria. The results showed that MAPKs pathway was a highly conserved signaling mechanism via conservative three degree of enzyme promoting cascade reactions (MAPKKK→MAPKK→MAPK) to activate transcription factor and regulate specific gene expression. It is proved that MAPKs pathway participates in regulating chondrocyte proliferation, differentiation and apoptosis in the articular cartilage, and maladjustment in MAPKs pathway plays a key role in osteoarthritis initiation and development. Clearing the specific mechanism of MAPKs pathway in osteoarthritis will help the targeted treatment for osteoarthritis.

CLC Number: