Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (37): 6951-6955.doi: 10.3969/j.issn.2095-4344.2012.37.023

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Warm needling regulates the prostaglandin E2 in a rat model of lumbar nerve root compression

Xie Yan-yan, Wu Yao-chi   

  1. Department of Acupuncture, Moxibustion and Massage, Shanghai No. 6 People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China
  • Received:2012-06-09 Revised:2012-06-19 Online:2012-09-09 Published:2012-09-09
  • Contact: Wu Yao-chi, Professor, Doctoral supervisor, Chief physician, Department of Acupuncture, Moxibustion and Massage, Shanghai No. 6 People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China wuyaochi@online.sh.cn
  • About author:Xie Yan-yan★, Master, Attending physician, Department of Acupuncture, Moxibustion and Massage, Shanghai No. 6 People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China xieyanyan13579@126.com

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Abstract:

BACKGROUND: Studies have demonstrated that warm needling exerts an important role in prostaglandin E2 expression in a rat model of lumbar nerve root compression.
OBJECTIVE: To explore the regulating effects of warm-needling on prostaglandin E2 expression of rat models of lumbar nerve root compression, and to compare the efficacy of acupuncture and meloxicam.
METHODS: Sixty Sprague-Dawley rats were randomly divided into five groups. They were normal group, model group, meloxicam group, acupuncture group and warm needling group. Rats in the latter four groups were prepared for rat models of lumbar nerve root compression by placing silicone films. The rats in the normal group were not modeled and had no therapy. The rats in the model group were modeled but not treated. After modeling, the rats in the meloxicam, acupuncture and warm needling groups were subjected to intragastric administration of 3.75 mg/kg meloxicam, acupuncture and warm needling for 14 days, respectively.
RESULTS AND CONCLUSION: Meloxicam, acupuncture, warm-needling all could reduce the content of prostaglandin E2 in rats with lumbar nerve root compression (P < 0.01). Compared to meloxicam and acupuncture, warm needling could better reduce the content of prostaglandin E2 (P < 0.01). The findings indicate that warm needling can effectively reduce the content of prostaglandin E2 in rats with lumbar nerve root compression.

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