Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (34): 6382-6388.doi: 10.3969/j.issn.2095-4344.2012.34.023

Previous Articles     Next Articles

Drug-, molecular-, hormone- and stem cells-targeted therapies for osteoporosis

Zhang Jie1, Tian Jing2   

  1. 1Second Medical School of Southern Medical University, Guangzhou 510282, Guangdong Province, China;
    2Orthopaedia Center, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China
  • Received:2012-03-26 Revised:2012-03-26 Online:2012-08-19 Published:2012-08-19
  • Contact: Tian Jing, Master, Professor, Associate chief physician, Master’s supervisor, Orthopaedia Center, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China tian_jing6723@ yahoo.com.cn
  • About author:Zhang Jie, Second Medical School of Southern Medical University, Guangzhou 510282, Guangdong Province, China Kamizj891026@ 126.com

PDF

429

Abstract:

BACKGROUND: Osteoporosis fractures and other complications can result in a severe impact in the quality of life of older people.
OBJECTIVE: To explore the progress in targeted therapy for osteoporosis in order to promote its clinical application.
METHODS: A computer-based online search of PubMed database and CNKI database between May 1997 and December 2011 was performed to search related articles with the key words of “targeted therapy, bone target, stem cell, osteoporosis, treatment” in English and Chinese, respectively. Literatures related to targeted therapy for osteoporosis on osteoporosis were selected; in the same field, the articles published lately in authoritative journals were preferred.
RESULTS AND CONCLUSION: A total of 148 literatures were primarily selected, and 38 documents were involved for summary according to inclusion criteria. Targeted treatment of osteoporosis has become a focus in the treatment of osteoporosis. Current research involves drug-targeted, molecular-targeted, hormone-targeted, receptor-targeted and stem cell-target therapies. Drug-, molecular- and hormone-targeted therapies are the most common methods to treat osteoporosis. Commonly used drugs include tetracycline, bisphosphonates, denosumab. However, targeted therapy for osteoporosis has not yet fully mature, and its clinical side effects limit its further development that there are still many issues to be resolved.

CLC Number: