Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (33): 6228-6232.doi: 10.3969/j.issn.2095-4344.2012.33.029

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Application of platelet-rich plasma for bone repair and its mechanism

Zhou Bin, Liao Qi   

  1. Second Department of Orthopedics, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
  • Received:2011-12-03 Revised:2012-01-06 Online:2012-08-12 Published:2012-08-12
  • Contact: Liao Qi, Professor, Chief physician, Master’s supervisor, Second Department of Orthopedics, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China liaoqi@medmail.com.cn
  • About author:Zhou Bin★, Studying for master’s degree, Second Department of Orthopedics, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China zhoubin8501@ 163.com

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Abstract:

BACKGROUND: Presently, it is widely accepted that platelet-rich plasma can accelerate bone repair. However, the mechanism of platelet-rich plasma in promoting bone repair has not been clarified; the best method to apply the platelet-rich plasma is still not definite.
OBJECTIVE: To review the application and mechanism of platelet-rich plasma on bone repair in recent years.
METHODS: A computer-based retrieval was performed by the first author in PubMed database and CNKI database to search papers about the application of platelet-rich plasma on bone repair and the mechanism of action. The key words were “platelet-rich plasma, growth factor, bone repair” in Chinese and English, respectively. The papers that did not meet the purposes of the author or obsolete and repeated were excluded. A total of 25 papers were included according to the inclusion criteria.
RESULTS AND CONCLUSION: Platelet-rich plasma is highly concentrated plasma enriched with platelets and various growth factors. Generally, the combination of many high-concentration growth factors released from blood platelet degranulation during polymerization could stimulate bone formation and accelerate bone repair. The effect of single platelet-rich plasma for bone repair is inferior to that of platelet-rich plasma compound with other substances.

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